Structure-Function Features and Effects on Blood Coagulation of Snake Venom Serine Proteases

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 动物活性蛋白多肽组学

	Structure-Function Features and Effects on Blood Coagulation of Snake Venom Serine Proteases
	Zhang Y; Lee WH; Cao R; Lu QM; Wang WY; Xiong YL
刊名	动物学研究
	1998
卷号	19 期号:2 页码:97-106
关键词	Venoms Proteases Blood coagulation
ISSN号	0254-5853
其他题名	蛇毒丝氨酸蛋白酶结构与功能特性及其对血液凝固系统的作用
中文摘要	蛇毒,特别是蝰亚科和腹亚科蛇毒,含有大量丝氨酸蛋白酶。这是自然界长期进化过程中演化出的一类既和哺乳动物蛋白酶相似,又存在相当程度的结构与功能分化的生物大分子,通过激活、灭活和转变机体中的凝血因子而广泛作用于血液凝固系统。它们的一级序列和胰蛋白酶-激肽释放酶同源。它们具有相同的活性中心构造和酶催化机制,但活性中心外可变区序列的差异造成了它们底物专一性差异,进一步体现为生物学和药理学功能的差异。
英文摘要	Snake venoms,especially those from the two subfamilies,Crotalinae and Viperinae,contained a lot of serine proteases.They were responsible for the hemorrhage,shock,or disorder of blood coagulation after envenomation.They acted,by activating,inactivating,or other converting effects,on almost all the components of hemostatic and fibrinolytic systems.Their sequences were homologous to trypsin-kallikrein serine proteases.Variation of primary sequences out of active center results in the difference of substrate specificities and the further difference of biological and pharmacological activities.Because of their common and unique properties compared to their physiological corresponding factors,snake venom proteases are proved to be an excellent model for the study of protease substrate discriminating mechanism.Furthermore,they have found an important position both in basic research and application of hemostasis and thrombosis in clinic.
收录类别	其他
资助信息	国家自然科学基金,云南省后备人才培养基金,中国科学院“九五”青年基金
原文出处	199819297.pdf
语种	中文
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/1979]
专题	昆明动物研究所_动物活性蛋白多肽组学昆明动物研究所_动物毒素室昆明动物研究所_其他
作者单位	Animal Toxinological Department,Kunming Institute of Zoology,the Chinese Academy of Sciences,Kunming 650223
推荐引用方式 GB/T 7714	Zhang Y,Lee WH,Cao R,et al. Structure-Function Features and Effects on Blood Coagulation of Snake Venom Serine Proteases[J]. 动物学研究,1998,19(2):97-106.
APA	Zhang Y,Lee WH,Cao R,Lu QM,Wang WY,&Xiong YL.(1998).Structure-Function Features and Effects on Blood Coagulation of Snake Venom Serine Proteases.动物学研究,19(2),97-106.
MLA	Zhang Y,et al."Structure-Function Features and Effects on Blood Coagulation of Snake Venom Serine Proteases".动物学研究 19.2(1998):97-106.