Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice

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	Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice
	Ruan GP 1; Yao X 1; Yang SJ 2; Wang JX 1; Shu F 1; Li ZA 1; Liu JF 1; Pang RQ[]1; Pan XH[]1
刊名	JOURNAL OF IMMUNOLOGY RESEARCH
	2014
卷号	2014 期号:X 页码:e530501
通讯作者	pangrq2000@aliyun.com ; xinghuapan@aliyun.com
合作状况	其它
英文摘要	Background. Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. Methods. We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. Results. After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls. The percentage of CD4(+)CD25(+)Foxp3(+) T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation. Conclusions. The results showed that H-UC-MSCs could repair lesions in B6.Fas mice such that all of the relevant disease indicators in B6.Fas mice were restored to the levels observed in normal C57BL/6 mice.
收录类别	其他
资助信息	This work was supported by the National Natural Sci- ence Foundation of China (31172170), 973 Projects (2012- CB518106), the Special Project of High-New Technology Industrial Development in Yunnan Province (201204), and the National Support Program (2014BAI01B01)
语种	英语
WOS记录号	WOS:000347830200001
公开日期	2015-02-13
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8259]
专题	管理、支撑部门_大型仪器中心
作者单位	1.Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China 2.Kunming Biological Diversity Regional Center of Large Apparatus and Equipment, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Ruan GP,Yao X,Yang SJ,et al. Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2014,2014(X):e530501.
APA	Ruan GP.,Yao X.,Yang SJ.,Wang JX.,Shu F.,...&Pan XH[*].(2014).Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice.JOURNAL OF IMMUNOLOGY RESEARCH,2014(X),e530501.
MLA	Ruan GP,et al."Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice".JOURNAL OF IMMUNOLOGY RESEARCH 2014.X(2014):e530501.