Ovarian response to gonadotropin stimulation in juvenile rhesus monkeys

	Ovarian response to gonadotropin stimulation in juvenile rhesus monkeys
	Yang S 1,2; He X 2; Niu Y 2; Hildebrandt TB 3; Jewgenow K 3; Goeritz F 3; Tang X 2; Chang Y 2; Zhou Q 4; Ji W[*]2
刊名	THERIOGENOLOGY
	2009
卷号	72 期号:2 页码:243-250
关键词	Breeding season Gonadotropin Juvenile rhesus monkey Ovarian stimulation rhFSH
ISSN号	0093-691X
通讯作者	wji@mail.kiz.ac.cn
合作状况	其它
英文摘要	The objective of this study was to investigate juvenile rhesus monkeys responding to various gonadotropin regimen Stimulations. Thirty-two prepubertal rhesus monkeys were randomly allocated into five groups for ovarian stimulation as follows: Groups I, II, and III were given 35, 18, and 9 IU recombinant human follicle-stimulating hormone (rhFSH), respectively, twice daily for 8 d: Group IV was given 18 IU rhFSH twice daily until the appearance of maximal increase in sex skin during the breeding season: and Group V was treated identically to Group 11 but during the nonbreeding season. In addition, nine menarchial monkeys (Group VI) were treated identically to Group II. Menarchial monkeys yielded two- to fivefold the numbers of MII oocytes (24.1) and almost twice the development potential of in vitro-fertilized oocytes (blastocyst rate: 50.0%) compared with those of the other groups. Moreover, prepubertal monkeys in Group V had approximately double the numbers of MII oocytes and in Groups Wand V twice the development potential compared with those of Groups 1 and 11, whereas Group III did not respond to stimulation. The most prominent sex skin swelling was in association with peak serum estradiol concentrations, and good responses to stimulation were associated with reduced body temperatures. All stimulated monkeys had normal reproductive performance at adulthood, except those in Group I. In conclusion, gonadotropin stimulation of menarchial monkeys could be appropriate for addressing the high cost and limited availability of rhesus monkeys in studying reproductive biology in primates.
收录类别	SCI
资助信息	This work was supported by research grants from the Chinese Major State Research Development Program (20060102A 1070), the Chinese National Basic Research Program (2007CB947701 and 2006CI3701505), the Chinese Academy of Sciences (KSCX2-YWR-47 and KSCX2-YW
原文出处	2009722243.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/5637]
专题	昆明动物研究所_生殖与发育生物学昆明动物研究所_哺乳动物胚胎发育昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.Biotechnology Research Center, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, People’s Republic of China 2.Kunming Primate Research Center and Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan Key Laboratory for Animal Reproduction, Kunming 650223, People’s Republic of China 3.Leibniz Institute for Zoo and Wildlife Research, PF 601103, 10252 Berlin, Germany 4.State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, People’s Republic of China
推荐引用方式 GB/T 7714	Yang S,He X,Niu Y,et al. Ovarian response to gonadotropin stimulation in juvenile rhesus monkeys[J]. THERIOGENOLOGY,2009,72(2):243-250.
APA	Yang S.,He X.,Niu Y.,Hildebrandt TB.,Jewgenow K.,...&Ji W[*].(2009).Ovarian response to gonadotropin stimulation in juvenile rhesus monkeys.THERIOGENOLOGY,72(2),243-250.
MLA	Yang S,et al."Ovarian response to gonadotropin stimulation in juvenile rhesus monkeys".THERIOGENOLOGY 72.2(2009):243-250.