An Evaluation of Association between a Novel Hippocampal Biology Related SNP (rs7294919) and Schizophrenia

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	An Evaluation of Association between a Novel Hippocampal Biology Related SNP (rs7294919) and Schizophrenia
	Liu JW 1,9; Numata S 2; Luo XJ 6; Kinoshita M 2; Shi YY 8; Li M[]1; Su B[]1; Ikeda M 3; Watanabe Y 4; Zheng XB 5
刊名	PLOS ONE
	2013
卷号	8 期号:11 页码:e80696
通讯作者	limingkiz@gmail.com ; sub@mail.kiz.ac.cn
合作状况	其它
英文摘要	Recent genetic analyses have implicated several candidate susceptibility variants for schizophrenia. The single nucleotide polymorphism (SNP) rs7294919 is likely a schizophrenia-susceptibility variant according to its significant association with hippocampal volume, hippocampus function, and cognitive performance as well as the nominal association with schizophrenia. However, all previous analyses were conducted only in Europeans, and whether rs7294919 is associated with schizophrenia in other populations are yet to be tested. Here, we conducted a case-control analysis of rs7294919 with schizophrenia in six independent Chinese (N = 3) and Japanese (N = 3) samples, including a total of 7,352 cases and 10,824 controls. The results of our association analysis were not able to confirm the association of rs7294919 with schizophrenia (p = 0.51 in total samples, odds ratio = 1.02 for allele[C]). The absence of rs7294919's association in Chinese and Japanese suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating associations of schizophrenia across different ethnic populations.
资助信息	This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant number, U1202225, 31130051 and 31071101), and the National Research Foundation Singapore under the National Medical Research Council Translational and Clinical Research Flagship Program (grant number, NMRC/TCR/003/2008).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10356]
专题	昆明动物研究所_比较基因组学昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_转化基因组
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto-cho, Tokushima, Japan 3.Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan 4.Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan 5.Human Genetics, Genome Institute of Singapore, A*STAR, Singapore 6.Flaum Eye Institute and Department of Ophthalmology, University of Rochester, Rochester, New York, United States of America 7.Institute of Mental Health, Singapore 8.Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China 9.University of Chinese Academy of Sciences, Beijing, China
推荐引用方式 GB/T 7714	Liu JW,Numata S,Luo XJ,et al. An Evaluation of Association between a Novel Hippocampal Biology Related SNP (rs7294919) and Schizophrenia[J]. PLOS ONE,2013,8(11):e80696.
APA	Liu JW.,Numata S.,Luo XJ.,Kinoshita M.,Shi YY.,...&Zheng XB.(2013).An Evaluation of Association between a Novel Hippocampal Biology Related SNP (rs7294919) and Schizophrenia.PLOS ONE,8(11),e80696.
MLA	Liu JW,et al."An Evaluation of Association between a Novel Hippocampal Biology Related SNP (rs7294919) and Schizophrenia".PLOS ONE 8.11(2013):e80696.