Accelerated evolution of the pituitary adenylate cyclase-activating polypeptide precursor gene during human origin

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	Accelerated evolution of the pituitary adenylate cyclase-activating polypeptide precursor gene during human origin
	Wang YQ 1,6; Qian YP 2; Zheng HK 3; Wang J 3; Lin AA 4; Cavalli-Sforza LL 4; Underhill PA 4; Chakraborty R 2; Yang S 1,6; Li J 2,5
刊名	Genetics
	2005
卷号	170 期号:2 页码:801–806
通讯作者	sub@mail.kiz.ac.cn
合作状况	其它
英文摘要	Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide abundantly expressed in the central nervous system and involved in regulating neurogenesis and neuronal signal transduction. The amino acid sequence of PACAP is extremely conserved across vertebrate species, indicating a strong functional constraint during the course of evolution. However, through comparative sequence analysis, we demonstrated that the PACAP precursor gene underwent an accelerated evolution in the human lineage since the divergence from chimpanzees, and the amino acid substitution rate in humans is at least seven times faster than that in other mammal species resulting from strong Darwinian positive selection. Eleven human-specific amino acid changes were identified in the PACAP precursors, which are conserved from murine to African apes. Protein structural analysis suggested that a putative novel neuropeptide might have originated during human evolution and functioned in the human brain. Our data suggested that the PACAP precursor gene underwent adaptive changes during human origin and may have contributed to the formation of human cognition.
收录类别	SCI
资助信息	This study was supported by agrant from the Chinese Academy Acad. Sci. USA 98: 13355–13360. of Sciences (KSCX2-SW-121), the National Natural Science Founda- Hedges, S. B., and S. Kumar, 1999 Divergence times of eutharian tion of China (30370755), and the Natural Science Foundation of mammals. Science 285: 2031. Yunnan Province of China.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9664]
专题	昆明动物研究所_比较基因组学昆明动物研究所_细胞与分子进化重点实验室
作者单位	1.Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Center for Genome Information, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267 3.Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 4.Department of Genetics, Stanford University, Stanford, California 94305 5.State Key Laboratory of Genetics Engineering and Center for Anthropological Studies, School of Life Sciences, Fudan University, Shanghai 200433, China 6.Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式 GB/T 7714	Wang YQ,Qian YP,Zheng HK,et al. Accelerated evolution of the pituitary adenylate cyclase-activating polypeptide precursor gene during human origin[J]. Genetics,2005,170(2):801–806.
APA	Wang YQ.,Qian YP.,Zheng HK.,Wang J.,Lin AA.,...&Liao CH.(2005).Accelerated evolution of the pituitary adenylate cyclase-activating polypeptide precursor gene during human origin.Genetics,170(2),801–806.
MLA	Wang YQ,et al."Accelerated evolution of the pituitary adenylate cyclase-activating polypeptide precursor gene during human origin".Genetics 170.2(2005):801–806.