Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 比较基因组学

	Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils
	Liu Y 1,2,3; Yang S 1,2; Lin AA 4; Cavalli-Sforza LL 4; Su B[*]1,2
刊名	JOURNAL OF MOLECULAR EVOLUTION
	2005
卷号	61 期号:5 页码:691–696
关键词	CXCR1 Darwinian positive selection G protein-coupled receptor Neutrophils Primates
通讯作者	sub@mail.kiz.ac.cn
合作状况	其它
英文摘要	Human neutrophils are a type of white blood cell, which forms an early line of defense against bacterial infections. Neutrophils are highly responsive to the chemokine, interleukin-8 (IL-8) due to the abundant distribution of CXCR1, one of the IL-8 receptors on the neutrophil cell surface. As a member of the GPCR family, CXCR1 plays a crucial role in the IL-8 signal transduction pathway in neutrophils. We sequenced the complete coding region of the CXCR1 gene in worldwide human populations and five representative nonhuman primate species. Our results indicate accelerated protein evolution in the human lineage, which was likely caused by Darwinian positive selection. The sliding window analysis and the codon-based neutrality test identified signatures of positive selection at the N-terminal ligand/receptor recognition domain of human CXCR1.
收录类别	SCI
资助信息	This study was supported by grants from the Chinese Academy of Sciences (KSCX2-SW-121), the National Natural Science Foundation of China (30370755, 30440018), the National 973 Project (2006CB701506), and the Natural Science Foundation of Yunnan Province of China.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9650]
专题	昆明动物研究所_比较基因组学昆明动物研究所_中国科学院昆明灵长类研究中心昆明动物研究所_细胞与分子进化开放实验室
作者单位	1.Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan, China 3.Graduate School of the Chinese Academy of Sciences, Beijing, China 4.Department of Genetics, Stanford University, Stanford, CA 94305, USA
推荐引用方式 GB/T 7714	Liu Y,Yang S,Lin AA,et al. Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils[J]. JOURNAL OF MOLECULAR EVOLUTION,2005,61(5):691–696.
APA	Liu Y,Yang S,Lin AA,Cavalli-Sforza LL,&Su B[*].(2005).Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils.JOURNAL OF MOLECULAR EVOLUTION,61(5),691–696.
MLA	Liu Y,et al."Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils".JOURNAL OF MOLECULAR EVOLUTION 61.5(2005):691–696.