ZNF804A and schizophrenia susceptibility in Asian populations

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 比较基因组学

	ZNF804A and schizophrenia susceptibility in Asian populations
	Li M 1,2; Shi CJ 3; Li ZQ 4,5; Liu JJ 6; Chong SA 7; Lee J 7; Wang Y 1,2; Liu XY 8; Shi YY 4,5; Yin LD 9
刊名	AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
	2012
卷号	159B 期号:7 页码:794-802
关键词	schizophrenia ZNF804A single nucleotide polymorphism (SNP) linkage disequilibrium (LD) structure Chinese populations
通讯作者	xuqi@pumc.edu.cn ; sub@mail.kiz.ac.cn
合作状况	其它
英文摘要	ZNF804A, a recently identified risk gene for schizophrenia, has been extensively investigated and the principle finding for this locus has been the association with SNP rs1344706 in populations of European ancestries. However, in Asian populations, only a few studies have been conducted for rs1344706 and the results were inconsistent. Here, we studied rs1344706 and schizophrenia susceptibility in multiple Asian casecontrol samples (10 Chinese and 2 Japanese samples; N?=?21,062), and the meta-analyses indicated non-significant association of rs1344706 with schizophrenia (P?=?0.26), suggesting the same SNP identified in European samples is not predisposing risk in Asians. Further genotyping and association analyses of a set of SNPs spanning the entire genomic region of ZNF804A (520?kb) identified no association except for SNP rs359895 (P?=?7.8?x?10-5, N?=?5,172), a newly reported risk SNP located in the ZNF804A promoter region with functional implications. This suggests that ZNF804A may also contribute to schizophrenia susceptibility in Asians although the risk SNP is different from that in Europeans, and it was supported by the detected up-regulation of ZNF804A mRNA expression in the blood cells of Chinese schizophrenia patients compared with normal controls (P?=?0.004). Additionally, the linkage disequilibrium (LD) structure analyses using data from HapMap indicated distinct LD blocks across ZNF804A between Chinese and Europeans, which may explain the different association patterns between them, and also highlight the compounding difficulty of genetic studies of complex diseases like schizophrenia when studying multiple ethnic populations.
收录类别	SCI
资助信息	NaturalScienceFoundation ofYunnanProvinceofChina;Grant number: 2009CD107; Grant sponsor: National Basic Research Program of China; Grant numbers: 2010CB529603, 2012CB517902; Grant sponsor: National Medical Research Council Translational and Clinical Research Flagship Program; Grant number: NMRC/TCR/003/2008.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9575]
专题	昆明动物研究所_比较基因组学昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_神经系统疾病昆明动物研究所_转化基因组
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Graduate School of Chinese Academy of Sciences, Beijing, China 3.National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Science and Peking Union Medical College, Tsinghua University, Beijing, China 4.Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China 5.Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China 6.Human Genetics, Genome Institute of Singapore, A*STAR, Singapore 7.Institute of Mental Health, Singapore 8.The Second People’s Hospital of Yuxi City, Yuxi, China 9.Yunnan Mental Health Hospital, Kunming, China
推荐引用方式 GB/T 7714	Li M,Shi CJ,Li ZQ,et al. ZNF804A and schizophrenia susceptibility in Asian populations[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2012,159B(7):794-802.
APA	Li M.,Shi CJ.,Li ZQ.,Liu JJ.,Chong SA.,...&Zheng XB.(2012).ZNF804A and schizophrenia susceptibility in Asian populations.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,159B(7),794-802.
MLA	Li M,et al."ZNF804A and schizophrenia susceptibility in Asian populations".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 159B.7(2012):794-802.