A Functional MiR-124 Binding-Site Polymorphism in IQGAP1 Affects Human Cognitive Performance

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	A Functional MiR-124 Binding-Site Polymorphism in IQGAP1 Affects Human Cognitive Performance
	Yang LX 1,5; Zhang R 1; Li M 1,5; Wu XJ 1,5; Wang JH 2; Huang L 1; Shi XD 3; Li QW 4; Su B[*]1
刊名	PLOS ONE
	2014
卷号	9 期号:9 页码:e107065
通讯作者	sub@mail.kiz.ac.cn
英文摘要	As a product of the unique evolution of the human brain, human cognitive performance is largely a collection of heritable traits. Rather surprisingly, to date there have been no reported cases to highlight genes that underwent adaptive evolution in humans and which carry polymorphisms that have a marked effect on cognitive performance. IQ motif containing GTPase activating protein 1 (IQGAP1), a scaffold protein, affects learning and memory in a dose-dependent manner. Its expression is regulated by miR-124 through the binding sites in the 3'UTR, where a SNP (rs1042538) exists in the core-binding motif. Here we showed that this SNP can influence the miR-target interaction both in vitro and in vivo. Individuals carrying the derived T alleles have higher IQGAP1 expression in the brain as compared to the ancestral A allele carriers. We observed a significant and male-specific association between rs1042538 and tactile performances in two independent cohorts. Males with the derived allele displayed higher tactual performances as compared to those with the ancestral allele. Furthermore, we found a highly diverged allele-frequency distribution of rs1042538 among world human populations, likely caused by natural selection and/or recent population expansion. These results suggest that current human populations still carry sequence variations that affect cognitive performances and that these genetic variants may likely have been subject to comparatively recent natural selection.
收录类别	SCI
资助信息	This work was supported by grants from the National 973 project of China (2011CBA00401 and 2012CBA01300), the National Natural Science Foundation of China (31130051, 31301028 and 31321002) and the Natural Science Foundation of Yunnan Province (2007C100M and 2009CD107). This study was also supported by funding from the West light Doctoral program.
语种	英语
WOS记录号	WOS:000341774800041
公开日期	2014-10-20
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8110]
专题	昆明动物研究所_比较基因组学昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_神经系统编码昆明动物研究所_转化基因组
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Laboratory of Primate Neuroscience Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Department of Biochemistry, Qujing Normal University, Qujing, China 4.College of Life Science, Liaoning Normal University, Dalian, China 5.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China
推荐引用方式 GB/T 7714	Yang LX,Zhang R,Li M,et al. A Functional MiR-124 Binding-Site Polymorphism in IQGAP1 Affects Human Cognitive Performance[J]. PLOS ONE,2014,9(9):e107065.
APA	Yang LX.,Zhang R.,Li M.,Wu XJ.,Wang JH.,...&Su B[*].(2014).A Functional MiR-124 Binding-Site Polymorphism in IQGAP1 Affects Human Cognitive Performance.PLOS ONE,9(9),e107065.
MLA	Yang LX,et al."A Functional MiR-124 Binding-Site Polymorphism in IQGAP1 Affects Human Cognitive Performance".PLOS ONE 9.9(2014):e107065.