Genetic Evidence of an East Asian Origin and Paleolithic Northward Migration of Y-chromosome Haplogroup N

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	Genetic Evidence of an East Asian Origin and Paleolithic Northward Migration of Y-chromosome Haplogroup N
	Shi H[]1; Qi XB 1; Zhong H 1,2; Peng Y 1; Zhang XM 1,3; Ma RZL 2; Su B[]1
刊名	PLOS ONE
	2013
卷号	8 期号:6 页码:e66102
通讯作者	shihong@mail.kiz.ac.cn ; sub@mail.kiz.ac.cn
合作状况	其它
英文摘要	The Y-chromosome haplogroup N-M231 (Hg N) is distributed widely in eastern and central Asia, Siberia, as well as in eastern and northern Europe. Previous studies suggested a counterclockwise prehistoric migration of Hg N from eastern Asia to eastern and northern Europe. However, the root of this Y chromosome lineage and its detailed dispersal pattern across eastern Asia are still unclear. We analyzed haplogroup profiles and phylogeographic patterns of 1,570 Hg N individuals from 20,826 males in 359 populations across Eurasia. We first genotyped 6,371 males from 169 populations in China and Cambodia, and generated data of 360 Hg N individuals, and then combined published data on 1,210 Hg N individuals from Japanese, Southeast Asian, Siberian, European and Central Asian populations. The results showed that the sub-haplogroups of Hg N have a distinct geographical distribution. The highest Y-STR diversity of the ancestral Hg N sub-haplogroups was observed in the southern part of mainland East Asia, and further phylogeographic analyses supports an origin of Hg N in southern China. Combined with previous data, we propose that the early northward dispersal of Hg N started from southern China about 21 thousand years ago (kya), expanding into northern China 12-18 kya, and reaching further north to Siberia about 12-14 kya before a population expansion and westward migration into Central Asia and eastern/northern Europe around 8.0-10.0 kya. This northward migration of Hg N likewise coincides with retreating ice sheets after the Last Glacial Maximum (22-18 kya) in mainland East Asia.
收录类别	SCI
资助信息	This study was supported by the National 973 Program of China (2012CBA01303 to HS; 2012CB518202 to XQ), the National Natural Science Foundation of China (91131001 and 31071101 to HS; 91231203 to BS) and the Natural Science Foundation of Yunnan Province (2009CD107 and 2010CI044 to HS).
语种	英语
WOS记录号	WOS:000322342800032
公开日期	2013-09-16
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7633]
专题	昆明动物研究所_比较基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Center for Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China 3.University of Chinese Academy of Sciences, Beijing, China
推荐引用方式 GB/T 7714	Shi H[*],Qi XB,Zhong H,et al. Genetic Evidence of an East Asian Origin and Paleolithic Northward Migration of Y-chromosome Haplogroup N[J]. PLOS ONE,2013,8(6):e66102.
APA	Shi H[].,Qi XB.,Zhong H.,Peng Y.,Zhang XM.,...&Su B[].(2013).Genetic Evidence of an East Asian Origin and Paleolithic Northward Migration of Y-chromosome Haplogroup N.PLOS ONE,8(6),e66102.
MLA	Shi H[*],et al."Genetic Evidence of an East Asian Origin and Paleolithic Northward Migration of Y-chromosome Haplogroup N".PLOS ONE 8.6(2013):e66102.