Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans | |
Shi L1; Li M1,2; Lin Q1,2; Qi XB1; Su B[*]1 | |
刊名 | BMC BIOLOGY |
2013 | |
卷号 | 11期号:X页码:e62 |
关键词 | MCPH1 E2F1 Brain size Primates Evolution Functional divergence |
通讯作者 | sub@mail.kiz.ac.cn |
合作状况 | 其它 |
英文摘要 |
Background: One of the key genes that regulate human brain size, MCPH1 has evolved under strong Darwinian positive selection during the evolution of primates. During this evolution, the divergence of MCPH1 protein sequences among primates may have caused functional changes that contribute to brain enlargement. |
收录类别 | SCI |
资助信息 | This work was supported by grants from the National 973 project of China (2011CBA00401), the National Natural Science Foundation of China (31130051), and the Natural Science Foundation of Yunnan Province, China (2009CD107) and the West light Doctoral program. |
语种 | 英语 |
WOS记录号 | WOS:000320042100001 |
公开日期 | 2013-07-12 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.42:8088/handle/152453/7569] |
专题 | 昆明动物研究所_比较基因组学 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_转化基因组 |
作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 East Jiao-Chang Road, Kunming, Yunnan 650223, PR China 2.University of the Chinese Academy of Sciences, No.19A Yuquan Road, Shijingshan District, Beijing, 100049, China |
推荐引用方式 GB/T 7714 | Shi L,Li M,Lin Q,et al. Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans[J]. BMC BIOLOGY,2013,11(X):e62. |
APA | Shi L,Li M,Lin Q,Qi XB,&Su B[*].(2013).Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans.BMC BIOLOGY,11(X),e62. |
MLA | Shi L,et al."Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans".BMC BIOLOGY 11.X(2013):e62. |
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