MicroRNA regulation and the variability of human cortical gene expression

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 比较基因组学

	MicroRNA regulation and the variability of human cortical gene expression
	Zhang R 1,2,3; Su B[*]1,2
刊名	NUCLEIC ACIDS RESEARCH
	2008
卷号	36 期号:14 页码:4621-4628
ISSN号	0305-1048
通讯作者	sub@mail.kiz.ac.cn
英文摘要	Understanding the driving forces of gene expression variation within human populations will provide important insights into the molecular basis of human phenotypic variation. In the genome, the gene expression variability differs among genes, and at present, most research has focused on identifying the genetic variants responsible for the within population gene expression variation. However, little is known about whether microRNAs (miRNAs), which are small noncoding RNAs modulating expression of their target genes, could have impact on the variability of gene expression. Here we demonstrate that miRNAs likely lead to the difference of expression variability among genes. With the use of the genome-wide expression data in 193 human brain samples, we show that the increased variability of gene expression is concomitant with the increased number of the miRNA seeds interacting with the target genes, suggesting a direct influence of miRNA on gene expression variability. Compared with the non-miRNA-target genes, genes targeted by more than two miRNA seeds have increased expression variability, independent of the miRNA types. In addition, single-nucleotide polymorphisms (SNPs) located in the miRNA binding sites could further increase the gene expression variability of the target genes. We propose that miRNAs are one of the driving forces causing expression variability in the human genome.
收录类别	SCI
资助信息	This study was supported by grants from the National 973 project of China (2007CB947701, 2007CB815705), the Chinese Academy of Sciences (KSCX1-YW-R-34), the National Natural Science Foundation of China (30525028, 30630013 and 30623007), and the Natural Science Foundation of Yunnan Province of China. We are grateful to Zhi-xiang Lu for his help in R programming. We also thank Leng Han, Ruo-lin Yang, Jin-kai Wang, Xia Zhang and Xin Li for their helpful discussions. Funding to pay the Open Access publication charges for this article was provided by the National 973 project of China (2007CB947701).
原文出处	2008364621.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/2167]
专题	昆明动物研究所_比较基因组学昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology 2.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming 650223, China 3.Graduate School of Chinese Academy of Sciences, Beijing 100039, China
推荐引用方式 GB/T 7714	Zhang R,Su B[*]. MicroRNA regulation and the variability of human cortical gene expression[J]. NUCLEIC ACIDS RESEARCH,2008,36(14):4621-4628.
APA	Zhang R,&Su B[*].(2008).MicroRNA regulation and the variability of human cortical gene expression.NUCLEIC ACIDS RESEARCH,36(14),4621-4628.
MLA	Zhang R,et al."MicroRNA regulation and the variability of human cortical gene expression".NUCLEIC ACIDS RESEARCH 36.14(2008):4621-4628.