Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites | |
Sun QS(孙强盛)1; Zhu H(朱华)1; Chen YJ(陈永剑)1; Yang XD(杨笑迪)1; Sun XW(孙兴文)1; Lin GQ(林国强)1 | |
刊名 | Angew. Chem.-Int. Edit. |
2015 | |
卷号 | 54期号:45页码:13253-13257 |
其他题名 | 螺酰胺催化的通过形成具有的活化位点的酮亚胺中间体构建高对映选择性的螺环羟吲哚 |
通讯作者 | 孙兴文 |
英文摘要 | A new method for the construction of five-membered spirocyclic oxindoles is based on a Michael-Mannich cascade reaction of a ketimine intermediated catalyzed by a bifunctional quinine-derived squaramide. The desired products were obtained in excellent yields (up to 94%) and stereoselectivities (up to >20:1 d.r., >99% ee). A scaled-up variant also proceeded smoothly showing that the one-pot reaction might find application in the synthesis of bioactive-compound libraries. |
学科主题 | 天然产物有机化学 |
收录类别 | SCI |
原文出处 | http://dx.doi.org/10.1002/anie.201506206 |
语种 | 英语 |
WOS记录号 | WOS:000363691500015 |
内容类型 | 期刊论文 |
源URL | [http://ir.sioc.ac.cn/handle/331003/39807] |
专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
作者单位 | 1.复旦大学 2.中科院上海有机化学研究所 |
推荐引用方式 GB/T 7714 | Sun QS,Zhu H,Chen YJ,et al. Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites[J]. Angew. Chem.-Int. Edit.,2015,54(45):13253-13257. |
APA | 孙强盛,朱华,陈永剑,杨笑迪,孙兴文,&林国强.(2015).Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites.Angew. Chem.-Int. Edit.,54(45),13253-13257. |
MLA | 孙强盛,et al."Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites".Angew. Chem.-Int. Edit. 54.45(2015):13253-13257. |
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