Pd-Catalyzed Highly Enantioselective Synthesis of Planar Chiral Ferrocenylpyridine Derivatives | |
Gao DW(高得伟)1; Zheng C(郑超)1; Gu Q(顾庆)1; You SL(游书力)1 | |
刊名 | Organometallics |
2015 | |
卷号 | 34期号:18页码:4618-4625 |
其他题名 | 钯催化高对映选择性合成平面手性二茂铁吡啶衍生物 |
通讯作者 | 顾庆 ; 游书力 |
英文摘要 | A highly efficient synthesis of planar chiral ferrocenylpyridine derivatives via Pd-catalyzed intramolecular C-H arylation was developed, and quantitative yields and excellent enantioselectivity were obtained for a wide range of substrates. Notably, the catalyst loading could be lowered to 0.2 mol %, which represents the highest catalytic efficiency found for asymmetric C-H bond activation (TON up to 495). These compounds could be easily transformed to pyridine N-oxides, displaying promising catalytic reactivity in the asymmetric opening of meso-epoxide. Moreover, computational investigations were conducted to clarify the origin of the excellent enantioselectivity. The compatibility of large-scale synthesis and low catalyst loading should enhance the practicality of the synthetic application of the current method. |
学科主题 | 金属有机化学 |
收录类别 | SCI |
原文出处 | http://dx.doi.org/10.1021/acs.organomet.5b00730 |
语种 | 英语 |
WOS记录号 | WOS:000362056400021 |
内容类型 | 期刊论文 |
源URL | [http://ir.sioc.ac.cn/handle/331003/39643] |
专题 | 上海有机化学研究所_金属有机化学国家重点实验室 |
作者单位 | 1.中科院上海有机化学研究所, 金属有机化学国家重点实验室 2.天津化学化工协同创新中心 |
推荐引用方式 GB/T 7714 | Gao DW,Zheng C,Gu Q,et al. Pd-Catalyzed Highly Enantioselective Synthesis of Planar Chiral Ferrocenylpyridine Derivatives[J]. Organometallics,2015,34(18):4618-4625. |
APA | 高得伟,郑超,顾庆,&游书力.(2015).Pd-Catalyzed Highly Enantioselective Synthesis of Planar Chiral Ferrocenylpyridine Derivatives.Organometallics,34(18),4618-4625. |
MLA | 高得伟,et al."Pd-Catalyzed Highly Enantioselective Synthesis of Planar Chiral Ferrocenylpyridine Derivatives".Organometallics 34.18(2015):4618-4625. |
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