Copper(I)-Catalyzed A(3)-Coupling Based Reaction of Alkynes, Aldehydes, and Amines: An Efficient Approach to 2,5-Polysubstituted Dihydrofurans and 2,5-Disubstituted Furans

CORC > 上海有机化学研究所 > 中国科学院上海有机化学研究所 > 金属有机化学国家重点实验室

	Copper(I)-Catalyzed A(3)-Coupling Based Reaction of Alkynes, Aldehydes, and Amines: An Efficient Approach to 2,5-Polysubstituted Dihydrofurans and 2,5-Disubstituted Furans
	Fan W(范武)1; Ma SM(麻生明)1
刊名	Eur. J. Org. Chem.
	2015
期号	16 页码:3531-3539
其他题名	亚铜催化的炔、醛、胺的A3偶联反应: 一种有效合成2,5-多取代的二氢呋喃和2,5-二取代呋喃的方法
通讯作者	麻生明
英文摘要	An efficient and practical A(3)-coupling based reaction that gives a variety of 2,5-polysubstituted dihydrofurans and 2,5-disubstituted furan derivatives has been developed. This domino copper-catalyzed three-component coupling reaction of propargylic alcohol, ethyl glyoxalate, and an amine affords a propargylic amine intermediate, which undergoes an alkyne-allene isomerization followed by a cyclization to yield the dihydrofuran. Upon treatment with CH3I and base, the latter was smoothly converted into a 2,5-disubstituted furan. Alternatively, the furan derivatives can be directly prepared by a two-step reaction sequence.
学科主题	金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/ejoc.201500209
语种	英语
WOS记录号	WOS:000355265000016
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39601]
专题	上海有机化学研究所_金属有机化学国家重点实验室
作者单位	1.华东师范大学 2.中科院上海有机化学研究所, 金属有机化学国家重点实验室
推荐引用方式 GB/T 7714	Fan W,Ma SM. Copper(I)-Catalyzed A(3)-Coupling Based Reaction of Alkynes, Aldehydes, and Amines: An Efficient Approach to 2,5-Polysubstituted Dihydrofurans and 2,5-Disubstituted Furans[J]. Eur. J. Org. Chem.,2015(16):3531-3539.
APA	范武,&麻生明.(2015).Copper(I)-Catalyzed A(3)-Coupling Based Reaction of Alkynes, Aldehydes, and Amines: An Efficient Approach to 2,5-Polysubstituted Dihydrofurans and 2,5-Disubstituted Furans.Eur. J. Org. Chem.(16),3531-3539.
MLA	范武,et al."Copper(I)-Catalyzed A(3)-Coupling Based Reaction of Alkynes, Aldehydes, and Amines: An Efficient Approach to 2,5-Polysubstituted Dihydrofurans and 2,5-Disubstituted Furans".Eur. J. Org. Chem. .16(2015):3531-3539.