Enantioselective synthesis of 4-substituted tetrahydroisoquinolines via palladium-catalyzed intramolecular Friedel-Crafts type allylic alkylation of phenols

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	Enantioselective synthesis of 4-substituted tetrahydroisoquinolines via palladium-catalyzed intramolecular Friedel-Crafts type allylic alkylation of phenols
	Zhao ZL(赵正乐)1; Xu QL(许庆龙)1; Gu Q(顾庆)1; Wu XY(伍新燕)1; You SL(游书力)1
刊名	Org. Biomol. Chem.
	2015
卷号	13 期号:10 页码:3086-3092
其他题名	钯催化苯酚的分子内Friedel-Crafts型烯丙基烷基化反应不对称合成4-取代四氢异喹啉化合物
通讯作者	伍新燕 ; 游书力
英文摘要	Palladium-catalyzed asymmetric intramolecular Friedel-Crafts type allylic alkylation reaction of phenols was developed under mild conditions. In the presence of Pd-2(dba)(3) with (1R,2R)-DACH-phenyl Trost ligand (L2) in toluene at 50 degrees C, the reaction provides various C4 substituted tetrahydroisoquinolines with moderate to excellent yields, regioselectivity and enantioselectivity.
学科主题	金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1039/c4ob02574a
语种	英语
WOS记录号	WOS:000350674400033
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39573]
专题	上海有机化学研究所_金属有机化学国家重点实验室
作者单位	1.华东理工大学 2.中科院上海有机化学研究所, 金属有机化学国家重点实验室
推荐引用方式 GB/T 7714	Zhao ZL,Xu QL,Gu Q,et al. Enantioselective synthesis of 4-substituted tetrahydroisoquinolines via palladium-catalyzed intramolecular Friedel-Crafts type allylic alkylation of phenols[J]. Org. Biomol. Chem.,2015,13(10):3086-3092.
APA	赵正乐,许庆龙,顾庆,伍新燕,&游书力.(2015).Enantioselective synthesis of 4-substituted tetrahydroisoquinolines via palladium-catalyzed intramolecular Friedel-Crafts type allylic alkylation of phenols.Org. Biomol. Chem.,13(10),3086-3092.
MLA	赵正乐,et al."Enantioselective synthesis of 4-substituted tetrahydroisoquinolines via palladium-catalyzed intramolecular Friedel-Crafts type allylic alkylation of phenols".Org. Biomol. Chem. 13.10(2015):3086-3092.