Efficient Synthesis of Sterically Hindered Arenes Bearing Acyclic Secondary Alkyl Groups by Suzuki-Miyaura Cross-Couplings

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	Efficient Synthesis of Sterically Hindered Arenes Bearing Acyclic Secondary Alkyl Groups by Suzuki-Miyaura Cross-Couplings
	Li CX(李承喜); Chen TY(陈天宇); Li BW(李博文); Xiao GL(肖国兰); Tang WJ(汤文军)
刊名	Angew. Chem.-Int. Edit.
	2015
卷号	54 期号:12 页码:3792-3796
其他题名	利用Suzuki-Miyaura交叉偶联高效合成大位阻二级烷基芳烃
通讯作者	汤文军
英文摘要	Bulky P,P=O ligands were designed to inhibit isomerization and reduction side reactions during the cross coupling between sterically hindered aryl halides and alkylboronic acids. Suzuki-Miyaura cross-couplings between di-ortho-substituted aryl bromides and acyclic secondary alkylboronic acids have been achieved with high yields. The method has also enabled the preparation of ortho-alkoxy di-ortho-substituted arenes bearing isopropyl groups in excellent yields. The utility of the synthetic method has been demonstrated in a late-stage modification of estrone and in the application to a new synthetic route toward gossypol.
学科主题	金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/anie.201411518
语种	英语
WOS记录号	WOS:000351178300047
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39572]
专题	上海有机化学研究所_金属有机化学国家重点实验室
作者单位	中科院上海有机化学研究所, 生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Li CX,Chen TY,Li BW,et al. Efficient Synthesis of Sterically Hindered Arenes Bearing Acyclic Secondary Alkyl Groups by Suzuki-Miyaura Cross-Couplings[J]. Angew. Chem.-Int. Edit.,2015,54(12):3792-3796.
APA	李承喜,陈天宇,李博文,肖国兰,&汤文军.(2015).Efficient Synthesis of Sterically Hindered Arenes Bearing Acyclic Secondary Alkyl Groups by Suzuki-Miyaura Cross-Couplings.Angew. Chem.-Int. Edit.,54(12),3792-3796.
MLA	李承喜,et al."Efficient Synthesis of Sterically Hindered Arenes Bearing Acyclic Secondary Alkyl Groups by Suzuki-Miyaura Cross-Couplings".Angew. Chem.-Int. Edit. 54.12(2015):3792-3796.