Rational design and functional evolution of targeted peptides for bioanalytical applications

	Rational design and functional evolution of targeted peptides for bioanalytical applications
	Huang, Yanyan 1,2; Jin, Yulong 1,2; Zhao, Rui 1,2
刊名	SCIENCE CHINA-CHEMISTRY
	2016-10-01
卷号	59 期号:10 页码:1250-1257
关键词	peptide design screening targeted analysis biomedical applications
英文摘要	The complicated, highly dynamic and diverse nature of biosystems brings great challenges to the specific analysis of molecular processes of interest. Nature provides antibodies for the specific recognition of antigens, which is a straight-forward way for targeted analysis. However, there are still limitations during the practical applications due to the big size of the antibodies, which accelerate the discovery of small molecular probes. Peptides built from various optional building blocks and easily achieved by chemical synthetic approaches with predictable conformations, are versatile and can act as tailor-made targeting vehicles. In this mini review, we summarize the recent developments in the discovery of novel peptides for bioanalytical and biomedical applications. Progresses in peptide-library design and selection strategies are presented. Recent achievements in the peptide-guided detection, imaging and disease treatment are also focused.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35631]
专题	化学研究所_活体分析化学实验室
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Huang, Yanyan,Jin, Yulong,Zhao, Rui. Rational design and functional evolution of targeted peptides for bioanalytical applications[J]. SCIENCE CHINA-CHEMISTRY,2016,59(10):1250-1257.
APA	Huang, Yanyan,Jin, Yulong,&Zhao, Rui.(2016).Rational design and functional evolution of targeted peptides for bioanalytical applications.SCIENCE CHINA-CHEMISTRY,59(10),1250-1257.
MLA	Huang, Yanyan,et al."Rational design and functional evolution of targeted peptides for bioanalytical applications".SCIENCE CHINA-CHEMISTRY 59.10(2016):1250-1257.