Gem-difluoromethylated and trifluoromethylated derivatives of DMDP-related iminosugars: synthesis and glycosidase inhibition

	Gem-difluoromethylated and trifluoromethylated derivatives of DMDP-related iminosugars: synthesis and glycosidase inhibition
	Li, Yi-Xian 1; Kinami, Kyoko 2; Hirokami, Yuki 2; Kato, Atsushi 2; Su, Jia-Kun 1; Jia, Yue-Mei 1; Fleet, George W. J.3,4; Yu, Chu-Yi 1,4
刊名	ORGANIC & BIOMOLECULAR CHEMISTRY
	2016
卷号	14 期号:7 页码:2249-2263
英文摘要	Gem-difluoromethylated and trifluoromethylated derivatives of DMDP-related iminosugars have been synthesized from cyclic nitrones 12, 13, 18, ent-18 or 23 and nitrone-derived aldehydes 20 or ent-20. The fluorinated iminosugars were assayed against various glycosidases, and ent-8 showed moderate but selective alpha-L-rhamnosidase inhibition. Difluoro or trifluoro units influenced the inhibitory activities of iminosugars in a more complex manner than single fluoro substitution. This may be correlated with their highly hydrophobic character and strong electron-withdrawing effect.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35862]
专题	化学研究所_分子识别与功能实验室
作者单位	1.Chinese Acad Sci, CAS Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China 2.Toyama Univ, Dept Hosp Pharm, 2630 Sugitani, Toyama 9300194, Japan 3.Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England 4.Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Peoples R China
推荐引用方式 GB/T 7714	Li, Yi-Xian,Kinami, Kyoko,Hirokami, Yuki,et al. Gem-difluoromethylated and trifluoromethylated derivatives of DMDP-related iminosugars: synthesis and glycosidase inhibition[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2016,14(7):2249-2263.
APA	Li, Yi-Xian.,Kinami, Kyoko.,Hirokami, Yuki.,Kato, Atsushi.,Su, Jia-Kun.,...&Yu, Chu-Yi.(2016).Gem-difluoromethylated and trifluoromethylated derivatives of DMDP-related iminosugars: synthesis and glycosidase inhibition.ORGANIC & BIOMOLECULAR CHEMISTRY,14(7),2249-2263.
MLA	Li, Yi-Xian,et al."Gem-difluoromethylated and trifluoromethylated derivatives of DMDP-related iminosugars: synthesis and glycosidase inhibition".ORGANIC & BIOMOLECULAR CHEMISTRY 14.7(2016):2249-2263.