Synergistic Effect of Human Serum Albumin and Fullerene on Gd-DO3A for Tumor-Targeting Imaging

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	Synergistic Effect of Human Serum Albumin and Fullerene on Gd-DO3A for Tumor-Targeting Imaging
	Zhang, Ying 1,2; Zou, Toujun 1,2; Guan, Mirong 1,2; Zhen, Mingming 1; Chen, Daiqin 1,2; Guan, Xiangping 3; Han, Hongbin 3; Wang, Chunru 1; Shu, Chunying 1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2016-05-11
卷号	8 期号:18 页码:11246-11254
关键词	fullerene macromolecular MRI contrast agent contrast enhancement tumor-targeting imaging low toxicity
英文摘要	A macromolecular magnetic resonance imaging (MRI) contrast agent was successfully synthesized by conjugating the gadolinium/1,4,7,10-tetraazacydododecane-1,4,7-tetracetic acid complex (Gd-DO3A) with 6,6-phenyl-C-61 butyric acid (PC(61)BA) and upon further modification with human serum albumin (HSA). The final product, PC(61)BA-(Gd-DO3A)/HSA, has a high stability and exhibits a much higher relaxivity (r(1) = 89.1 mM(-1) s(-1) at 0.5 T, 300 K) than Gd-DO3A (r(1) = 4.7 mM(-1) s(-1)) does under the same condition, producing the synergistic positive effect of HSA and C-60 on the relaxivity of Gd-DO3A. The in vivo MR images of PC(61)BA-(Gd-DO3A)/HSA-treated tumor-bearing mice show strong signal enhancement for the tumor area due to the enhanced permeability and retention effect. The maximum accumulation of PC(61)BA-(Gd-DO3A)/HSA at the tumor site was achieved at 4 h postinjection, which may guide surgery. The results from the hematology and histological observations indicate that PC(61)BA-(Gd-DO3A)/HSA has no obvious toxicity in vivo. These unique properties of PC(61)BA-(Gd-DO3A)/HSA enable them to be highly efficient for tumor-targeting MRI in vivo, possibly providing a good solution for tumor diagnosis.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/36081]
专题	化学研究所_分子纳米结构与纳米技术实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ying,Zou, Toujun,Guan, Mirong,et al. Synergistic Effect of Human Serum Albumin and Fullerene on Gd-DO3A for Tumor-Targeting Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(18):11246-11254.
APA	Zhang, Ying.,Zou, Toujun.,Guan, Mirong.,Zhen, Mingming.,Chen, Daiqin.,...&Shu, Chunying.(2016).Synergistic Effect of Human Serum Albumin and Fullerene on Gd-DO3A for Tumor-Targeting Imaging.ACS APPLIED MATERIALS & INTERFACES,8(18),11246-11254.
MLA	Zhang, Ying,et al."Synergistic Effect of Human Serum Albumin and Fullerene on Gd-DO3A for Tumor-Targeting Imaging".ACS APPLIED MATERIALS & INTERFACES 8.18(2016):11246-11254.