Gd@C-82-(ethylenediamine)(8) Nanoparticle: A New High-Efficiency Water -Soluble ROS Scavenger

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	Gd@C-82-(ethylenediamine)(8) Nanoparticle: A New High-Efficiency Water -Soluble ROS Scavenger
	Li, Jie 1,2; Guan, Mirong 1,2; Wang, Taishan 1; Zhen, Mingming 1,2; Zhao, Fuwen 1,2; Shu, Chunying 1; Wang, Chunru 1,2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2016-10-05
卷号	8 期号:39 页码:25770-25776
关键词	ROS scavenger Gd@C-82-(EDA)(8) nanoparticles conjugation cytoprotective effect cellular uptake
英文摘要	It is important to maintain a reactive oxygen species (ROS) balance in organisms; thus, a valid ROS scavenger with good biocompatibility is urgently required. To prepare a high-efficiency ROS scavenger, multiple ethylenediamine (EDA) groups are bonded for the first time to a metallofullerene Gd@C-82 to obtain water-soluble Gd@C-82-(EDA)(8) nanoparticles (NPs) through a facile solid liquid reaction. Gd@C-82-(EDA)(8) NPs with a relatively better conjugation possess an excellent capability to scavenge hydroxyl radicals. Moreover, Gd@C-82-(EDA)(8) NPs exhibited a remarkable cytoprotective effect against H2O2-induced injuries to human epidermal keratinocytes-adult (HEK-a) cells at a low concentration of 2.5 mu M. In contrast, Gd@C-82-(OH)(26) NPs that modified with hydroxyls show an apparent protective effect at a much higher concentration of 40 mu M. This outstanding cytoprotective performance of Gd@C-82-(EDA)(8) NPs is mainly attributed to their extremely high cellular uptake and comparably strong conjugation. Gd@C-82-(EDA)(8) NPs with good biocompatibility exhibit excellent ROS scavenging capability even at a significantly low concentration, which promotes its versatile applications in cosmetics and biomedicine.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35666]
专题	化学研究所_分子纳米结构与纳米技术实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Jie,Guan, Mirong,Wang, Taishan,et al. Gd@C-82-(ethylenediamine)(8) Nanoparticle: A New High-Efficiency Water -Soluble ROS Scavenger[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(39):25770-25776.
APA	Li, Jie.,Guan, Mirong.,Wang, Taishan.,Zhen, Mingming.,Zhao, Fuwen.,...&Wang, Chunru.(2016).Gd@C-82-(ethylenediamine)(8) Nanoparticle: A New High-Efficiency Water -Soluble ROS Scavenger.ACS APPLIED MATERIALS & INTERFACES,8(39),25770-25776.
MLA	Li, Jie,et al."Gd@C-82-(ethylenediamine)(8) Nanoparticle: A New High-Efficiency Water -Soluble ROS Scavenger".ACS APPLIED MATERIALS & INTERFACES 8.39(2016):25770-25776.