A facile route for the fabrication of a novel ZnS shell/Cu-Zn-In-S nanosheets/TiO2 nanorods heterojunction was reported in this work. Especially, the quaternary Cu-Zn-In-S nanosheets were synthesized creatively from the ternary ZnIn2S4 nanosheets by partial exchange reaction, leading to substantial enhancement on the light absorbance. Such heterojunction could increase the surface area and accelerate the charge transfer resulting from its hierarchical 2D/1D structure and favorable energy bands. Moreover, the ZnS coating acted as a passivation layer as well as a potential barrier, significantly suppressing the interface recombination. The above synergistic effects resulted in the largely increased photocurrent density from 0.34 mA cm(-2) for the pristine TiO2 to 0.81 mA cm(-2) for the heterojunction at 0.8 V vs RHE.