Badiranji Buya Keli, a Traditional Uyghur Medicine, Induces Vasodilation in Rat Artery: Signaling Mediated by Nitric Oxide Production in Endothelial Cells

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	Badiranji Buya Keli, a Traditional Uyghur Medicine, Induces Vasodilation in Rat Artery: Signaling Mediated by Nitric Oxide Production in Endothelial Cells
	Miernisha, A (Miernisha, A.); Bi, CWC (Bi, Cathy W. C.); Cheng, LKW (Cheng, Lily K. W.); Xing, JG (Xing, J. G.); Liu, J (Liu, J.); Maiwulanjiang, M (Maiwulanjiang, M.); Aisa, HA (Aisa, H. A.); Dong, TNTX (Dong, Tina T. X.); Lin, HQ (Lin, Huangquan); Huang, Y (Huang, Y.)
刊名	PHYTOTHERAPY RESEARCH
	2016
卷号	30 期号:1 页码:16-24
关键词	Badiranji Buya Keli Dracocephalum moldavicaL anti-platelet aggregation vasodilation nitric oxide
英文摘要	Badiranji Buya Keli (BBK) is a traditional Uyghur medicine derived from Dracocephalum Moldavica Herba (DMH, the aerial part of Dracocephalum moldavica L.). BBK has been widely used in treating cardiovascular and cerebrovascular diseases. Here, the quality control of BBK was established by using HPLC analysis of rosmarinic acid and tilianin. After chemical standardization, the biological effects of BBK was tested. First, BBK inhibited platelet aggregation of rabbit plasma. Second, BBK induced vasodilation in rat aortic ring, and this effect was partially mediated by nitric oxide (NO) production in endothelial cells. Third, BBK induced NO production in cultured human umbilical vein endothelial cells (HUVECs). In HUVECs, the phosphorylation of endothelial NO synthase (eNOS) was markedly increased after application of BBK. Pre-treatment with the eNOS blocker N-nitro-l-arginine methyl ester hydrochloride could abolish BBK-induced NO production and eNOS phosphorylation. Taken together, these results suggest that BBK could exert beneficial effects in cardiovascular system, which may provide parts of molecular explanation to account for its traditional usage in Uyghur medicine.
收录类别	SCI
WOS记录号	WOS:000367919300003
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/4706]
专题	新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室新疆理化技术研究所_资源化学研究室
作者单位	1.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China 2.Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Hong Kong, Peoples R China 3.Chinese Univ Hong Kong, Sch Biomed Sci, Li Ka Shing Inst Hlth Sci, Inst Vasc Med, Hong Kong, Hong Kong, Peoples R China 4.Xinjiang Inst Mat Med, Urumqi, Peoples R China 5.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Nat Prod Chem, Urumqi, Peoples R China
推荐引用方式 GB/T 7714	Miernisha, A ,Bi, CWC ,Cheng, LKW ,et al. Badiranji Buya Keli, a Traditional Uyghur Medicine, Induces Vasodilation in Rat Artery: Signaling Mediated by Nitric Oxide Production in Endothelial Cells[J]. PHYTOTHERAPY RESEARCH,2016,30(1):16-24.
APA	Miernisha, A .,Bi, CWC .,Cheng, LKW .,Xing, JG .,Liu, J .,...&Tsim, KWK .(2016).Badiranji Buya Keli, a Traditional Uyghur Medicine, Induces Vasodilation in Rat Artery: Signaling Mediated by Nitric Oxide Production in Endothelial Cells.PHYTOTHERAPY RESEARCH,30(1),16-24.
MLA	Miernisha, A ,et al."Badiranji Buya Keli, a Traditional Uyghur Medicine, Induces Vasodilation in Rat Artery: Signaling Mediated by Nitric Oxide Production in Endothelial Cells".PHYTOTHERAPY RESEARCH 30.1(2016):16-24.