New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk

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	New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk
	Li, Y (Li, Yan); Yili, A (Yili, Abulimiti); Li, J (Li, Jun); Muhamat, A (Muhamat, Aziz); Aisa, HA (Aisa, Haji Akber)
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2016
卷号	26 期号:8 页码:1983-1987
关键词	Fritillaria pallidiflora Isosteroidal alkaloid Yibeinones A-D Tracheal relaxant effect
英文摘要	Four new isosteroidal alkaloids, yibeinones A-D (1-4), along with four known ones, imperialine-3 beta-D-glucoside (5), imperialine (6), imperialine beta-N-oxide (7), and dongbeinine (8), were isolated from the bulbs of Fritillaria pallidiflora. Their structures were confirmed on the basis of extensive spectroscopic analysis or comparison with the data in the literatures (known compounds). Compounds 2, 3, 4, and 6 showed an apparent concentration-dependant relaxation of isolated tracheal preparation, amongst 3 and 6 exhibited significant effects with pA(2) values of 6.19 +/- 0.02 and 8.41 +/- 0.10, and EC50 values of 0.65 +/- 0.02 mu mol L-1 and 4.40 +/- 0.90 nmol L-1, respectively.
收录类别	SCI
WOS记录号	WOS:000372509000024
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/4668]
专题	新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室新疆理化技术研究所_资源化学研究室
作者单位	1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plants Resources & Chem Arid Zone, Beijing South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China 2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Beijing South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Li, Y ,Yili, A ,Li, J ,et al. New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(8):1983-1987.
APA	Li, Y ,Yili, A ,Li, J ,Muhamat, A ,&Aisa, HA .(2016).New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(8),1983-1987.
MLA	Li, Y ,et al."New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.8(2016):1983-1987.