The widespread occurrence of different classes of pharmaceutically active compounds (PhACs) and pesticides have been found in wastewater, surface water, ground water and drinking water. PhACs and pesticides show a wide range of persistence in aquatic environments, and some are highly persistent, which have been found to resist water and wastewater treatment. As a new and the most promising development in the research of advanced oxidation water treatment, heterogeneous catalytic ozonation has been attracting the increasing interest because of its potentially higher effectiveness in the degradation and mineralization of refractory organic pollutants and lower negative effect on water quality. In this work, the two kinds of organic pollutants were selected as the model compounds to help evaluate the activity and properties of the synthetic supported catalysts. In addition, the catalytic ozonation process of organic pollutants in water and the catalytic ozonation mechanism at the water-solid interface were studied. On these bases, continuous flow experiments were carried out in the fixed bed reactor in order to investigate its feasibility for practical water treatment. The main research results are shown as follows.