Alzheimer's disease and gut microbiota

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	Alzheimer's disease and gut microbiota
	Hu, Xu; Wang, Tao; Jin, Feng
刊名	SCIENCE CHINA-LIFE SCIENCES
	2016-10-01
卷号	59 期号:10 页码:1006-1023
关键词	Alzheimer's disease gut microbiota leaky gut leaky brain diet infection hygiene hypothesis
ISSN号	1674-7305
英文摘要	Alzheimer's disease (AD) is a most common neurodegenerative disorder, which associates with impaired cognition. Gut microbiota can modulate host brain function and behavior via microbiota-gut-brain axis, including cognitive behavior. Germ-free animals, antibiotics, probiotics intervention and diet can induce alterations of gut microbiota and gut physiology and also host cognitive behavior, increasing or decreasing risks of AD. The increased permeability of intestine and blood-brain barrier induced by gut microbiota disturbance will increase the incidence of neurodegeneration disorders. Gut microbial metabolites and their effects on host neurochemical changes may increase or decrease the risk of AD. Pathogenic microbes infection will also increase the risk of AD, and meanwhile, the onset of AD support the "hygiene hypothesis". All the results suggest that AD may begin in the gut, and is closely related to the imbalance of gut microbiota. Modulation of gut microbiota through personalized diet or beneficial microbiota intervention will probably become a new treatment for AD.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biology
研究领域[WOS]	Life Sciences & Biomedicine - Other Topics
关键词[WOS]	AMYOTROPHIC-LATERAL-SCLEROSIS ; SIMPLEX-VIRUS TYPE-1 ; BLOOD-BRAIN-BARRIER ; HELICOBACTER-PYLORI INFECTION ; MILD COGNITIVE IMPAIRMENT ; POPULATION-BASED CAIDE ; METHYLAMINO-L-ALANINE ; AMYLOID-BETA-PEPTIDE ; HYGIENE HYPOTHESIS ; CALORIC RESTRICTION
收录类别	SCI
语种	英语
WOS记录号	WOS:000385416200004
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/20693]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Hu, Xu,Wang, Tao,Jin, Feng. Alzheimer's disease and gut microbiota[J]. SCIENCE CHINA-LIFE SCIENCES,2016,59(10):1006-1023.
APA	Hu, Xu,Wang, Tao,&Jin, Feng.(2016).Alzheimer's disease and gut microbiota.SCIENCE CHINA-LIFE SCIENCES,59(10),1006-1023.
MLA	Hu, Xu,et al."Alzheimer's disease and gut microbiota".SCIENCE CHINA-LIFE SCIENCES 59.10(2016):1006-1023.