Altered intrinsic brain activity in patients with familial cortical myoclonic tremor and epilepsy: An amplitude of low-frequency fluctuation study

	Altered intrinsic brain activity in patients with familial cortical myoclonic tremor and epilepsy: An amplitude of low-frequency fluctuation study
	Wang, Pu; Luo, Cheng; Dong, Li; Bin, Yi; Ma, Shi; Yao, Dezhong; Guo, Fuqiang; Yang, Zhenglin
刊名	JOURNAL OF THE NEUROLOGICAL SCIENCES
	2015
卷号	351 期号:42371 页码:133-139
关键词	RESTING-STATE FMRI LOBE EPILEPSY DEFAULT MODE BOLD SIGNAL GENE SCHIZOPHRENIA LOCALIZATION MUTATIONS CHILDREN FEATURES
通讯作者	Guo, FQ (reprint author), Sichuan Acad Med Sci, Dept Neurol, Chengdu, Sichuan, Peoples R China.
产权排序	6
合作状况	国内
英文摘要	Purpose: To investigate localized cerebral function abnormalities in patients with familial cortical myoclonic tremor and epilepsy (FCMTE) using resting-state functional magnetic resonance imaging (fMRI). Methods: Seven patients with FCMTE from a Chinese family, seven patients with essential tremor (ET), and ten healthy controls were recruited. Amplitude of low-frequency fluctuation (ALFF) analysis was utilized to reveal the potential functional changes in patients with FCMTE. Results: Significant differences in the bilateral frontal lobe and fusiform gyrus among the three groups were revealed by one-way analysis of variance (ANOVA). The t-tests between groups were performed to compare ALFF in these ROIs. The FCMTE subjects exhibited decreased ALFF in the right fusiform gyrus and posterior cingulate cortex (PCC) with increased ALFF in the frontal lobe, compared with the ET and healthy control groups. Furthermore, the ALFF in the frontal lobe was positively correlated with the duration of tremor in patients with FCMTE and ET. Conclusion: These findings suggest that frontal cortex and PCC impairment might be related to the epileptic activity and that the abnormality of the fusiform gyrus may be associated with impairment of visuospatial in FCMTE. Due to the positive correlation between the duration of tremor and ALFF in the frontal lobe, changes in the frontal lobe could be a potential indicator of a candidate causative gene for FCMTE. (C) 2015 Elsevier B.V. All rights reserved.
学科主题	Neurosciences & Neurology
类目[WOS]	Clinical Neurology ; Neurosciences
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/27590]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Wang, Pu,Luo, Cheng,Dong, Li,et al. Altered intrinsic brain activity in patients with familial cortical myoclonic tremor and epilepsy: An amplitude of low-frequency fluctuation study[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES,2015,351(42371):133-139.
APA	Wang, Pu.,Luo, Cheng.,Dong, Li.,Bin, Yi.,Ma, Shi.,...&Yang, Zhenglin.(2015).Altered intrinsic brain activity in patients with familial cortical myoclonic tremor and epilepsy: An amplitude of low-frequency fluctuation study.JOURNAL OF THE NEUROLOGICAL SCIENCES,351(42371),133-139.
MLA	Wang, Pu,et al."Altered intrinsic brain activity in patients with familial cortical myoclonic tremor and epilepsy: An amplitude of low-frequency fluctuation study".JOURNAL OF THE NEUROLOGICAL SCIENCES 351.42371(2015):133-139.