Computational probing protein-protein interactions targeting small molecules | |
Wang, Yong-Cui1; Chen, Shi-Long1; Deng, Nai-Yang2; Wang, Yong3 | |
刊名 | bioinformatics
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2016-01-15 | |
卷号 | 32期号:2页码:226-234 |
英文摘要 | motivation: with the booming of interactome studies, a lot of interactions can be measured in a high throughput way and large scale datasets are available. it is becoming apparent that many different types of interactions can be potential drug targets. compared with inhibition of a single protein, inhibition of protein-protein interaction (ppi) is promising to improve the specificity with fewer adverse side-effects. also it greatly broadens the drug target search space, which makes the drug target discovery difficult. computational methods are highly desired to efficiently provide candidates for further experiments and hold the promise to greatly accelerate the discovery of novel drug targets. |
WOS标题词 | science & technology ; life sciences & biomedicine ; technology ; physical sciences |
类目[WOS] | biochemical research methods ; biotechnology & applied microbiology ; computer science, interdisciplinary applications ; mathematical & computational biology ; statistics & probability |
研究领域[WOS] | biochemistry & molecular biology ; biotechnology & applied microbiology ; computer science ; mathematical & computational biology ; mathematics |
关键词[WOS] | interaction network ; drug discovery ; interaction prediction ; interaction map ; kernel methods ; database ; inhibitors ; sequence ; machine ; identification |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000368360100010 |
内容类型 | 期刊论文 |
源URL | [http://ir.nwipb.ac.cn/handle/363003/6500] ![]() |
专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China 2.China Agr Univ, Coll Sci, Beijing 100083, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Yong-Cui,Chen, Shi-Long,Deng, Nai-Yang,et al. Computational probing protein-protein interactions targeting small molecules[J]. bioinformatics,2016,32(2):226-234. |
APA | Wang, Yong-Cui,Chen, Shi-Long,Deng, Nai-Yang,&Wang, Yong.(2016).Computational probing protein-protein interactions targeting small molecules.bioinformatics,32(2),226-234. |
MLA | Wang, Yong-Cui,et al."Computational probing protein-protein interactions targeting small molecules".bioinformatics 32.2(2016):226-234. |
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