Computational probing protein-protein interactions targeting small molecules

	Computational probing protein-protein interactions targeting small molecules
	Wang, Yong-Cui 1; Chen, Shi-Long 1; Deng, Nai-Yang 2; Wang, Yong 3
刊名	bioinformatics
	2016-01-15
卷号	32 期号:2 页码:226-234
英文摘要	motivation: with the booming of interactome studies, a lot of interactions can be measured in a high throughput way and large scale datasets are available. it is becoming apparent that many different types of interactions can be potential drug targets. compared with inhibition of a single protein, inhibition of protein-protein interaction (ppi) is promising to improve the specificity with fewer adverse side-effects. also it greatly broadens the drug target search space, which makes the drug target discovery difficult. computational methods are highly desired to efficiently provide candidates for further experiments and hold the promise to greatly accelerate the discovery of novel drug targets.
WOS标题词	science & technology ; life sciences & biomedicine ; technology ; physical sciences
类目[WOS]	biochemical research methods ; biotechnology & applied microbiology ; computer science, interdisciplinary applications ; mathematical & computational biology ; statistics & probability
研究领域[WOS]	biochemistry & molecular biology ; biotechnology & applied microbiology ; computer science ; mathematical & computational biology ; mathematics
关键词[WOS]	interaction network ; drug discovery ; interaction prediction ; interaction map ; kernel methods ; database ; inhibitors ; sequence ; machine ; identification
收录类别	SCI
语种	英语
WOS记录号	WOS:000368360100010
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/6500]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China 2.China Agr Univ, Coll Sci, Beijing 100083, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yong-Cui,Chen, Shi-Long,Deng, Nai-Yang,et al. Computational probing protein-protein interactions targeting small molecules[J]. bioinformatics,2016,32(2):226-234.
APA	Wang, Yong-Cui,Chen, Shi-Long,Deng, Nai-Yang,&Wang, Yong.(2016).Computational probing protein-protein interactions targeting small molecules.bioinformatics,32(2),226-234.
MLA	Wang, Yong-Cui,et al."Computational probing protein-protein interactions targeting small molecules".bioinformatics 32.2(2016):226-234.