Comparison of mercury sulfides with mercury chloride and methylmercury on hepatic P450, phase-2 and transporter gene expression in mice

	Comparison of mercury sulfides with mercury chloride and methylmercury on hepatic P450, phase-2 and transporter gene expression in mice
	Xu, S. F.1; Wu, Q.1; Zhang, B. B.1; Li, H.1; Xu, Y. S.1; Du, Y. Z.2; Wei, L. X.2; Liu, J.1
刊名	journal of trace elements in medicine and biology
	2016
卷号	37 页码:37-43
关键词	Zuotai Mercury sulfide Mercury chloride Methylmercury Cytochrome P450 Phase-2 genes Transporters
英文摘要	zuotai (mainly beta-hgs) and zhusha (also called as cinnabar, mainly alpha-hgs) are used in traditional medicines in combination with herbs or even drugs in the treatment of various disorders, while mercury chloride (hgcl2) and methylmercury (mehg) do not have known medical values but are highly toxic. this study aimed to compare the effects of mercury sulfides with hgcl2 and mehg on hepatic drug processing gene expression. mice were orally administrated with zuotai (beta-hgs, 30 mg/kg), alpha-hgs (hgs, 30 mg/kg), hgcl2 (33.6 mg/kg), or mehg (3.1 mg/kg) for 7 days, and the expression of genes related to phase-1 drug metabolism (p450), phase-2 conjugation, and phase-3 (transporters) genes were examined. the mercurials at the dose and duration used in the study did not have significant effects on the expression of cytochrome p450 1-4 family genes and the corresponding nuclear receptors, except for a slight increase in ppar alpha and cyp4a10 by hgcl2. the expressions of udp-glucuronosyltransferase and sulfotransferase were increased by hgcl2 and mehg, but not by zuotai and hgs. hgcl2 decreased the expression of organic anion transporter (oatp1a1), but increased oatp1a4. both hgcl2 and mehg increased the expression of multidrug resistance-associated protein genes (mrpl, mrp2, mrp3, and mrp4). zuotai and hgs had little effects on these transporter genes. in conclusion, zuotai and hgs are different from hgcl2 and mehg in hepatic drug processing gene expression; suggesting that chemical forms of mercury not only affect their disposition and toxicity, but also affect their effects on the expression of hepatic drug processing genes. (c) 2016 elsevier gmbh. all rights reserved.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	biochemistry & molecular biology ; endocrinology & metabolism
研究领域[WOS]	biochemistry & molecular biology ; endocrinology & metabolism
关键词[WOS]	tibetan medicine zuotai ; messenger-rna expression ; herb-drug interactions ; metabolism ; acid ; cytochrome-p450 ; cinnabar ; cadmium ; injury ; cyp1a1
收录类别	SCI
语种	英语
WOS记录号	WOS:000381840800005
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/6429]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
作者单位	1.Zunyi Med Coll, Minist Educ, Key Lab Basic Pharmacol, Zunyi, Peoples R China 2.Chinese Acad Sci, Northwest Plateau Inst Biol, Xining, Peoples R China
推荐引用方式 GB/T 7714	Xu, S. F.,Wu, Q.,Zhang, B. B.,et al. Comparison of mercury sulfides with mercury chloride and methylmercury on hepatic P450, phase-2 and transporter gene expression in mice[J]. journal of trace elements in medicine and biology,2016,37:37-43.
APA	Xu, S. F..,Wu, Q..,Zhang, B. B..,Li, H..,Xu, Y. S..,...&Liu, J..(2016).Comparison of mercury sulfides with mercury chloride and methylmercury on hepatic P450, phase-2 and transporter gene expression in mice.journal of trace elements in medicine and biology,37,37-43.
MLA	Xu, S. F.,et al."Comparison of mercury sulfides with mercury chloride and methylmercury on hepatic P450, phase-2 and transporter gene expression in mice".journal of trace elements in medicine and biology 37(2016):37-43.