Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives

	Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives
	Hu, Linfeng 1,2; Meng, Xiangtao 1; Xing, Ronge1 ; Liu, Song 1; Chen, Xiaolin 1; Qin, Yukun 1; Yu, Huahua1 ; Li, Pengcheng1
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2016-09-15
卷号	26 期号:18 页码:4548-4551
关键词	Chitosan 6-N-substituted chitosan Antibacterial activity Antifungal activity
英文摘要	Three novel 6-N-substituted chitosan derivatives were designed and synthesised and characterized by FTIR and NMR. The degree of substitution was calculated by elemental analysis results. The antimicrobial activities of the target compounds were evaluated by twofold serial broth dilution method and poisoned food technique. The antifungal activities of 6-aminoethylamino-6-deoxy chitosan (3), 6-butylamino-6deoxy chitosan (4) and 6-pyridyl-6-deoxy chitosan (5) were significantly increased against Rhizoctonia cerealis, Fusarium oxysporum and Botrytis cinerea, and the inhibition rate ranged from 22.48% to 63.56% at the concentration of 0.2 mg/mL. The compound 3 had better antibacterial activities than chitosan, and the minimum inhibition concentration of which ranged between 6.25 and 25 mg/L against gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis and Bacillus anthracis) and gram-negative bacteria (Escherichia coli, Salmonella typhi). The antibacterial activities of 6-N-substituted chitosan tended to increase with the increase of the number of -NH2 group. (C) 2015 Elsevier Ltd. All rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000382263800031
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/135863]
专题	海洋研究所_海洋生物技术研发中心海洋研究所_海洋环境工程技术研究发展中心
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Henan Inst Sci & Technol, Sch Chem & Chem Engn, Xinxiang 453003, Peoples R China
推荐引用方式 GB/T 7714	Hu, Linfeng,Meng, Xiangtao,Xing, Ronge,et al. Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(18):4548-4551.
APA	Hu, Linfeng.,Meng, Xiangtao.,Xing, Ronge.,Liu, Song.,Chen, Xiaolin.,...&Li, Pengcheng.(2016).Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(18),4548-4551.
MLA	Hu, Linfeng,et al."Design, synthesis and antimicrobial activity of 6-N-substituted chitosan derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.18(2016):4548-4551.