Identification of the Bcl-2 family protein gene BOK from orange-spotted grouper (Epinephelus coioides) involved in SGIV infection

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	Identification of the Bcl-2 family protein gene BOK from orange-spotted grouper (Epinephelus coioides) involved in SGIV infection
	Cai, Jia; Yu, Dapeng; Wei, Shina; Tang, Jufen; Lu, Yishan; Wu, Zaohe; Qin, Qiwei; Jian, Jichang
刊名	FISH & SHELLFISH IMMUNOLOGY
	2016
卷号	52 页码:2016-09-15
关键词	Epinephelus coioides BOK Singapore grouper iridovirus (SGIV) Viral gene Viral replication
通讯作者	Jian, JC (reprint author), Guangdong Ocean Univ, Coll Fishery, 1 Haida Rd, Zhanjiang 524088, Peoples R China. ; Qin, QW (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China.
中文摘要	Apoptosis plays vital roles in many physiological process and immune response. BOK is one of the central regulators in apoptosis. In this study, a new BOX homolog (Ec-BOK) was cloned and characterized from Orange-spotted grouper, Epinephelus coioides. Ec-BOK encoded a 210 amino acid peptides which shared 97% identity to Stegastes partitus BOK protein, contained four BH domains and one transmembrane region. Ec-BOK widely expressed in all analyzed tissues with the higher expressions in kidney and spleen. Its expression level was up-regulated after SGIV infection in vitro. Further analysis revealed that over expression of Ec-BOK inhibited viral genes transcriptions and virus replication in fish cell. Our findings suggested that Ec-BOK might play a role in the immune response against virus. (C) 2016 Elsevier Ltd. All rights reserved.
学科主题	Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/15421]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Cai, Jia,Yu, Dapeng,Wei, Shina,et al. Identification of the Bcl-2 family protein gene BOK from orange-spotted grouper (Epinephelus coioides) involved in SGIV infection[J]. FISH & SHELLFISH IMMUNOLOGY,2016,52:2016-09-15.
APA	Cai, Jia.,Yu, Dapeng.,Wei, Shina.,Tang, Jufen.,Lu, Yishan.,...&Jian, Jichang.(2016).Identification of the Bcl-2 family protein gene BOK from orange-spotted grouper (Epinephelus coioides) involved in SGIV infection.FISH & SHELLFISH IMMUNOLOGY,52,2016-09-15.
MLA	Cai, Jia,et al."Identification of the Bcl-2 family protein gene BOK from orange-spotted grouper (Epinephelus coioides) involved in SGIV infection".FISH & SHELLFISH IMMUNOLOGY 52(2016):2016-09-15.