A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66

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	A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66
	Huang, Huiming; Li, Huayue; Qiu, Yanhong; Hou, Lukuan; Ju, Jianhua; Li, Wenli
刊名	MARINE DRUGS
	2016
卷号	14 期号:10 页码:184
关键词	deepsea-derived Streptomyces dioic acid wblA(so)
通讯作者	Li, WL (reprint author), Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China. ; Li, WL (reprint author), Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China.
英文摘要	The wblA(so) gene functions as a global regulatory gene in a negative manner in deepsea-derived Streptomyces somaliensis SCSIO ZH66. A new dioic acid (1) as well as two known butenolides (2 and 3) were isolated from the wblA(so) mutant strain of S. somaliensis SCSIO ZH66. The structure of 1 was elucidated by a combination of spectroscopic analyses, including MS and NMR techniques. In the cell growth inhibitory evaluation, compound 3 exhibited moderate activity against the human hepatic carcinoma cell line (Huh7.5) with an IC50 value of 19.4 g/mL, while compounds 1 and 2 showed null activity up to 100 g/mL.
学科主题	Pharmacology & Pharmacy
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/15281]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Huang, Huiming,Li, Huayue,Qiu, Yanhong,et al. A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66[J]. MARINE DRUGS,2016,14(10):184.
APA	Huang, Huiming,Li, Huayue,Qiu, Yanhong,Hou, Lukuan,Ju, Jianhua,&Li, Wenli.(2016).A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66.MARINE DRUGS,14(10),184.
MLA	Huang, Huiming,et al."A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66".MARINE DRUGS 14.10(2016):184.