Cytotoxic Cytochalasins from Marine-Derived Fungus Arthrinium arundinis

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	Cytotoxic Cytochalasins from Marine-Derived Fungus Arthrinium arundinis
	Wang, Junfeng 1; Wang, Zhen 1; Ju, Zhiran 1; Wan, Junting 1; Liao, Shengrong 1; Lin, Xiuping 1; Zhang, Tianyu 1; Zhou, Xuefeng 1; Chen, Hao 1; Tu, Zhengchao 1
刊名	PLANTA MEDICA
	2015
卷号	81 期号:2 页码:160-166
关键词	Arthrinium arundinis Apiosporaceae sponge marine fungus cytochalasin cytotoxic activity
通讯作者	tu_zhengchao@gibh.ac.cn
英文摘要	Four new cytochalasins, arthriniumnins A-D (1-4), a new natural product, ketocytochalasin (5), as well as five known cytochalasin analogues (6-10) were isolated and identified from the fungus Arthrinium arundinis ZSDS1-F3 from the sponge Phakellia fusca. Their structures were elucidated by NMR spectroscopic and mass spectrometric analyses, as well as single crystal X-ray diffraction. Compounds 6 and 9 showed cytotoxicity against K562, A549, Huh-7, H1975, MCF-7, U937, BGC823, HL60, Hela, and MOLT-4 cell lines, with IC50 values ranging from 1.13 to 47.4 mu M.
学科主题	Plant Sciences; Pharmacology & Pharmacy
原文出处	0032-0943
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/14896]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.[Wang, Zhen 2.Wan, Junting 3.Zhang, Tianyu 4.Tu, Zhengchao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China 5.[Wang, Junfeng 6.Liao, Shengrong 7.Lin, Xiuping 8.Zhou, Xuefeng 9.Liu, Yonghong] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510530, Guangdong, Peoples R China 10.[Chen, Hao] State Ocean Adm Republ China, Key Lab Marine Bioact Subst, Inst Oceanog 1, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Wang, Junfeng,Wang, Zhen,Ju, Zhiran,et al. Cytotoxic Cytochalasins from Marine-Derived Fungus Arthrinium arundinis[J]. PLANTA MEDICA,2015,81(2):160-166.
APA	Wang, Junfeng.,Wang, Zhen.,Ju, Zhiran.,Wan, Junting.,Liao, Shengrong.,...&Liu, Yonghong.(2015).Cytotoxic Cytochalasins from Marine-Derived Fungus Arthrinium arundinis.PLANTA MEDICA,81(2),160-166.
MLA	Wang, Junfeng,et al."Cytotoxic Cytochalasins from Marine-Derived Fungus Arthrinium arundinis".PLANTA MEDICA 81.2(2015):160-166.