Radiation induced degradation of antiepileptic drug primidone in aqueous solution

CORC > 上海光学精密机械研究所 > 中国科学院上海光学精密机械研究所 > 空间激光信息技术研究中心

	Radiation induced degradation of antiepileptic drug primidone in aqueous solution
	Liu, Ning ; Wang, Tao ; Zheng, Ming ; Lei, Jianqiu ; Tang, Liang ; Hu, Guyu ; Xu, Gang ; Wu, Minghong
刊名	chem. eng. j.
	2015
卷号	270 页码:66
通讯作者	tang, l (reprint author), shanghai univ, sch environm & chem engn, shanghai 200444, peoples r china.
英文摘要	the present study was to determine the effectiveness of electron beam irradiation for degradation of the antiepileptic drug primidone (pmd) in aqueous solution. the results showed that pmd degradation followed pseudo-first-order kinetics. the dose constant determined in this study ranged from 1.26 to 4.59 kgy(-1), and decreased with an increase in the pmd initial concentration, whereas the initial radiation chemical yield for the loss of pmd decreased with increasing of absorbed dose and increased as the pmd concentration increased. the effects of medium ph, the presence of so42-, so32-, co32-, hco3-, no3- and no2- anions, h2o2, iso-propanol, and saturated solutions of n-2, o-2, n2o were also investigated. the results demonstrated that the (oh)-o-center dot took the most important role in the degradation of pmd, while the reductive e(aq)(-) and h-center dot took the less important role in pmd degradation. major degradation products of pmd, including degradation intermediates, low weight organic acids and some inorganic ions were detected by lc/ms/ms and ic. formic acid, acetic acid, oxalic acid, maleic acid and no3-, nh4+ were identified in the irradiated solutions. possible pathways for pmd decomposition by electron beam irradiation in aqueous solution were proposed. (c) 2015 elsevier b.v. all rights reserved.
收录类别	SCI
语种	英语
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.siom.ac.cn/handle/181231/13955]
专题	上海光学精密机械研究所_空间激光信息技术研究中心
作者单位	1.[Liu, Ning 2.Wang, Tao] Univ Shanghai Sci & Technol, Sch Environm & Architecture, Shanghai 200093, Peoples R China 3.[Lei, Jianqiu 4.Hu, Guyu] Chinese Acad Sci, Shanghai Inst Opt & Fine Mech, Shanghai 201800, Peoples R China 5.[Zheng, Ming 6.Tang, Liang 7.Xu, Gang 8.Wu, Minghong] Shanghai Univ, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ning,Wang, Tao,Zheng, Ming,et al. Radiation induced degradation of antiepileptic drug primidone in aqueous solution[J]. chem. eng. j.,2015,270:66.
APA	Liu, Ning.,Wang, Tao.,Zheng, Ming.,Lei, Jianqiu.,Tang, Liang.,...&Wu, Minghong.(2015).Radiation induced degradation of antiepileptic drug primidone in aqueous solution.chem. eng. j.,270,66.
MLA	Liu, Ning,et al."Radiation induced degradation of antiepileptic drug primidone in aqueous solution".chem. eng. j. 270(2015):66.