Bio-inspired Dynamic Gradients Regulated by Supramolecular Bindings in Receptor-Embedded Hydrogel Matrices

	Bio-inspired Dynamic Gradients Regulated by Supramolecular Bindings in Receptor-Embedded Hydrogel Matrices
	Luan, Xinglong 1; Zhang, Yihe 1; Wu, Jing 2; Jonkheijm, Pascal 3; Li, Guangtao 4; Jiang, Lei 5; Huskens, Jurriaan 3; An, Qi 1
刊名	CHEMISTRYOPEN
	2016-08-01
卷号	5 期号:4 页码:331-338
关键词	cyclodextrin diffusion dynamic gradients hydrogels supramolecular binding
英文摘要	The kinetics of supramolecular bindings are fundamentally important for molecular motions and spatial-temporal distributions in biological systems, but have rarely been employed in preparing artificial materials. This report proposes a bio-inspired concept to regulate dynamic gradients through the coupled supramolecular binding and diffusion process in receptor-embedded hydrogel matrices. A new type of hydrogel that uses cyclodextrin (CD) as both the gelling moiety and the receptors is prepared as the diffusion matrices. The diffusible guest, 4-aminoazobenzene, quickly and reversibly binds to matrices-bound CD during diffusion and generates steeper gradients than regular diffusion. Weakened bindings induced through UV irradiation extend the gradients. Combined with numerical simulation, these results indicate that the coupled binding-diffusion could be viewed as slowed diffusion, regulated jointly by the binding constant and the equilibrium receptor concentrations, and gradients within a bio-relevant extent of 4mm are preserved up to 90h. This report should inspire design strategies of biomedical or cell-culturing materials.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35258]
专题	化学研究所_有机固体实验室
作者单位	1.China Univ Geosci, Beijing Key Lab Mat Utilizat Nonmetall Minerals &, Natl Lab Mineral Mat, Sch Mat Sci & Technol, Beijing 100083, Peoples R China 2.China Univ Geosci, Sch Sci, Beijing 100083, Peoples R China 3.Univ Twente, Mol Nanofabricat Grp, MESA Inst Nanotechnol, NL-7500 AE Enschede, Netherlands 4.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China 5.Chinese Acad Sci, Inst Chem, Beijing 100084, Peoples R China
推荐引用方式 GB/T 7714	Luan, Xinglong,Zhang, Yihe,Wu, Jing,et al. Bio-inspired Dynamic Gradients Regulated by Supramolecular Bindings in Receptor-Embedded Hydrogel Matrices[J]. CHEMISTRYOPEN,2016,5(4):331-338.
APA	Luan, Xinglong.,Zhang, Yihe.,Wu, Jing.,Jonkheijm, Pascal.,Li, Guangtao.,...&An, Qi.(2016).Bio-inspired Dynamic Gradients Regulated by Supramolecular Bindings in Receptor-Embedded Hydrogel Matrices.CHEMISTRYOPEN,5(4),331-338.
MLA	Luan, Xinglong,et al."Bio-inspired Dynamic Gradients Regulated by Supramolecular Bindings in Receptor-Embedded Hydrogel Matrices".CHEMISTRYOPEN 5.4(2016):331-338.