Biomimetic membrane-conjugated graphene nanoarchitecture for light-manipulating combined cancer treatment in vitro

CORC > 化学研究所 > 中国科学院化学研究所 > 胶体、界面与化学热力学实验室

	Biomimetic membrane-conjugated graphene nanoarchitecture for light-manipulating combined cancer treatment in vitro
	Qin, Chenchen ; Fei, Jinbo ; Cai, Peng ; Zhao, Jie ; Li, Junbai 1
刊名	JOURNAL OF COLLOID AND INTERFACE SCIENCE
	2016-11-15
卷号	482 页码:121-130
关键词	Biomimetic membrane Graphene oxide Drug delivery Cancer therapy
英文摘要	We report that through facile lipid self-assembly, biomimetic membrane-conjugated mesoporous silica coated graphene oxide is constructed as targeting nanocarrier toward efficient combination of photothermal therapy and chemotherapy. Impressively, the simple surface modification with folate-contained lipid bilayer allows the graphene-based nanoarchitecture above to be selectively internalized by tumor cells overexpressing relevant receptors. Compared to pure drug, 7-fold doxorubicin is delivered into tumor cells by the nanoarchitecture. After cellular internalization, upon near infrared light illumination, graphene oxide in the nanoarchitecture can convert light energy into heat to kill cancer cells partially. Simultaneously, hyperthermia will drive rapid release of doxorubicin from the nanoarchitecture above to further cause the death of more cancer cells. Thus, integrated cancer treatment with higher efficacy is achieved in vitro compared to that of individual therapy. (C) 2016 Elsevier Inc. All rights reserved.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35270]
专题	化学研究所_胶体、界面与化学热力学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing Natl Lab Mol Sci, North First St 2, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Qin, Chenchen,Fei, Jinbo,Cai, Peng,et al. Biomimetic membrane-conjugated graphene nanoarchitecture for light-manipulating combined cancer treatment in vitro[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2016,482:121-130.
APA	Qin, Chenchen,Fei, Jinbo,Cai, Peng,Zhao, Jie,&Li, Junbai.(2016).Biomimetic membrane-conjugated graphene nanoarchitecture for light-manipulating combined cancer treatment in vitro.JOURNAL OF COLLOID AND INTERFACE SCIENCE,482,121-130.
MLA	Qin, Chenchen,et al."Biomimetic membrane-conjugated graphene nanoarchitecture for light-manipulating combined cancer treatment in vitro".JOURNAL OF COLLOID AND INTERFACE SCIENCE 482(2016):121-130.