Hierarchical Structures of Bone and Bioinspired Bone Tissue Engineering

	Hierarchical Structures of Bone and Bioinspired Bone Tissue Engineering
	Liu, Yan 1; Luo, Dan 2,3; Wang, Tie 2
刊名	SMALL
	2016-09-14
卷号	12 期号:34 页码:4611-4632
英文摘要	Bone, as a mineralized composite of inorganic (mostly carbonated hydroxyapatite) and organic (mainly type I collagen) phases, possesses a unique combination of remarkable strength and toughness. Its excellent mechanical properties are related to its hierarchical structures and precise organization of the inorganic and organic phases at the nanoscale: Nanometersized hydroxyapatite crystals periodically deposit within the gap zones of collagen fibrils during bone biomineralization process. This hierarchical arrangement produces nanomechanical heterogeneities, which enable a mechanism for high energy dissipation and resistance to fracture. The excellent mechanical properties integrated with the hierarchical nanostructure of bone have inspired chemists and material scientists to develop biomimetic strategies for artificial bone grafts in tissue engineering (TE). This critical review provides a broad overview of the current mechanisms involved in bone biomineralization, and the relationship between bone hierarchical structures and the deformation mechanism. Our goal in this review is to inspire the application of these principles toward bone TE.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35292]
专题	化学研究所_活体分析化学实验室
作者单位	1.Peking Univ Sch & Hosp Stomatol, Dept Orthodont, Ctr Craniofacial Stem Cell Res & Regenerat, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.China Univ Petr, Inst New Energy, State Key Lab Heavy Oil Proc, Beijing 102249, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yan,Luo, Dan,Wang, Tie. Hierarchical Structures of Bone and Bioinspired Bone Tissue Engineering[J]. SMALL,2016,12(34):4611-4632.
APA	Liu, Yan,Luo, Dan,&Wang, Tie.(2016).Hierarchical Structures of Bone and Bioinspired Bone Tissue Engineering.SMALL,12(34),4611-4632.
MLA	Liu, Yan,et al."Hierarchical Structures of Bone and Bioinspired Bone Tissue Engineering".SMALL 12.34(2016):4611-4632.