Fluorographene nanosheets: a new carbon-based matrix for the detection of small molecules by MALDI-TOF MS

	Fluorographene nanosheets: a new carbon-based matrix for the detection of small molecules by MALDI-TOF MS
	Sun, Jie 1,3; Chen, Suming 1; Liu, Huihui 1; Xiong, Caiqiao 1; Wang, Jiyun 1; Xie, Xiaobo 1,3; Xue, Jinjuan 1,3; Chen, Penglei 2; Nie, Zongxiu 1,3,4
刊名	RSC ADVANCES
	2016
卷号	6 期号:102 页码:99714-99719
英文摘要	Fluorographene nanosheets (FG) were synthesized via one-pot chloroform-mediated sonochemical exfoliation under ambient conditions. For the first time, this material served as a novel matrix for the detection of small molecules by negative ion MALDI-TOF MS. The structural characterization and ionization mechanism of FG were illustrated. The unique properties of FG endow it with properties such as low background, excellent chemical compatibility and homogeneity over conventional carbon based matrices. Most significantly, application of FG as matrix resolved the contamination problem of conventional carbon based matrices to ion source. With the association of FG, a variety of small molecules containing amino acids, peptides, small metabolites, drugs and organonitrogen compounds were analyzed. The developed method was found to have excellent feasibility with biosystems. Based on this, qualitative analysis of sialic acid in human saliva, melatonin in human urine and in situ analysis of MCF-7 cells were done, besides, quantification of anti-cancer drug in human serum and uric acid in human urine were displayed. This work extends the application fields of FG and provides a good candidate of matrix for MALDI-TOF MS detection of small molecules.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35147]
专题	化学研究所_活体分析化学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Chem, Key Lab Colloid Interface & Chem Thermodynam, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Natl Ctr Mass Spectrometry Beijing, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Sun, Jie,Chen, Suming,Liu, Huihui,et al. Fluorographene nanosheets: a new carbon-based matrix for the detection of small molecules by MALDI-TOF MS[J]. RSC ADVANCES,2016,6(102):99714-99719.
APA	Sun, Jie.,Chen, Suming.,Liu, Huihui.,Xiong, Caiqiao.,Wang, Jiyun.,...&Nie, Zongxiu.(2016).Fluorographene nanosheets: a new carbon-based matrix for the detection of small molecules by MALDI-TOF MS.RSC ADVANCES,6(102),99714-99719.
MLA	Sun, Jie,et al."Fluorographene nanosheets: a new carbon-based matrix for the detection of small molecules by MALDI-TOF MS".RSC ADVANCES 6.102(2016):99714-99719.