A New Tetraphenylethylene-Derived Fluorescent Probe for Nitroreductase Detection and Hypoxic-Tumor-Cell Imaging

	A New Tetraphenylethylene-Derived Fluorescent Probe for Nitroreductase Detection and Hypoxic-Tumor-Cell Imaging
	You, Xue 1,2; Li, Lihong 1,2; Li, Xiaohua 1; Ma, Huimin 1,2; Zhang, Guanxin 1; Zhang, Deqing 1,2
刊名	CHEMISTRY-AN ASIAN JOURNAL
	2016-10-01
卷号	11 期号:20 页码:2918-2923
关键词	aggregation fluorescence imaging agents nitroreductase tetraphenylethylene
英文摘要	The fluorescence detection of nitroreductase ( NTR) and evaluation of the hypoxia status of tumor cells are vital, not only for clinical diagnoses and therapy, but also for biomedical research. Herein, we report the synthesis and application of a new fluorometric "turn-on" probe for the detection of NTR ( TPE-NO2) that takes advantage of the aggregation-induced emission of tetraphenylethylene. TPE-NO2 can detect NTR at concentrations as low as 5 ng mL(-1) in aqueous solution. The detection mechanism relied on the aggregation and deaggregation of tetraphenylethylene molecules. Moreover, this fluorescent probe can be used to monitor the hypoxia status of tumor cells through the detection of endogenous NTR.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35113]
专题	化学研究所_活体分析化学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Labs Organ Solids & Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	You, Xue,Li, Lihong,Li, Xiaohua,et al. A New Tetraphenylethylene-Derived Fluorescent Probe for Nitroreductase Detection and Hypoxic-Tumor-Cell Imaging[J]. CHEMISTRY-AN ASIAN JOURNAL,2016,11(20):2918-2923.
APA	You, Xue,Li, Lihong,Li, Xiaohua,Ma, Huimin,Zhang, Guanxin,&Zhang, Deqing.(2016).A New Tetraphenylethylene-Derived Fluorescent Probe for Nitroreductase Detection and Hypoxic-Tumor-Cell Imaging.CHEMISTRY-AN ASIAN JOURNAL,11(20),2918-2923.
MLA	You, Xue,et al."A New Tetraphenylethylene-Derived Fluorescent Probe for Nitroreductase Detection and Hypoxic-Tumor-Cell Imaging".CHEMISTRY-AN ASIAN JOURNAL 11.20(2016):2918-2923.