Fabrication of pH-Responsive Nanoparticles with an AIE Feature for Imaging Intracellular Drug Delivery

	Fabrication of pH-Responsive Nanoparticles with an AIE Feature for Imaging Intracellular Drug Delivery
	Wang, Xing 1; Yang, Yanyu 1,2; Zhuang, Yaping 1,2; Gao, Peiyuan 1,2; Yang, Fei 1,2; Shen, Hong 1; Guo, Hongxia 1,2; Wu, Decheng 1,2
刊名	BIOMACROMOLECULES
	2016-09-01
卷号	17 期号:9 页码:2920-2929
英文摘要	Here we have demonstrated a facile method for construction of self-assembled nanoparticles with excellent fluorescent properties by the synergetic combination of unique AIE effects and tadpole-shaped polymers. The introduction of acid-sensitive Schiff base bonds furnished the polymeric vesicles and micelles with unique pH responsiveness that can possess maximal drug-release controllability inside tumor cells upon changes in physical and chemical environments, but present good stability under physiological conditions. Having benefited from the efficient fluorescence resonance energy transfer (FRET), the DOX-loaded fluorescent aggregates were employed for intracellular imaging and self-localization in surveillance of systemic DOX delivery. Cytotoxicity assay of the DOX-loaded aggregates indicated a fast internalization and a high cellular proliferation inhibition to MCF-7 cells while the PEG-POSS-(TPE)(7) nanoparticles displayed no cytotoxicity, exhibiting excellent biocompatibility and biological imaging properties. These results indicated that these biodegradable nanoparticles, as a class of effective pH-responsive and visible nanocarriers, have the potential to improve smart drug delivery and enhance the antitumor efficacy for biomedical applications.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35302]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xing,Yang, Yanyu,Zhuang, Yaping,et al. Fabrication of pH-Responsive Nanoparticles with an AIE Feature for Imaging Intracellular Drug Delivery[J]. BIOMACROMOLECULES,2016,17(9):2920-2929.
APA	Wang, Xing.,Yang, Yanyu.,Zhuang, Yaping.,Gao, Peiyuan.,Yang, Fei.,...&Wu, Decheng.(2016).Fabrication of pH-Responsive Nanoparticles with an AIE Feature for Imaging Intracellular Drug Delivery.BIOMACROMOLECULES,17(9),2920-2929.
MLA	Wang, Xing,et al."Fabrication of pH-Responsive Nanoparticles with an AIE Feature for Imaging Intracellular Drug Delivery".BIOMACROMOLECULES 17.9(2016):2920-2929.