Benzoic-Imine-Based Physiological-pH-Responsive Materials for Biomedical Applications

	Benzoic-Imine-Based Physiological-pH-Responsive Materials for Biomedical Applications
	Qu, Xiaozhong 1,2; Yang, Zhenzhong 1
刊名	CHEMISTRY-AN ASIAN JOURNAL
	2016-10-01
卷号	11 期号:19 页码:2633-2641
关键词	benzoic imines biomedical applications drug delivery polymers responsive materials
英文摘要	The benzoic imine is a dynamic covalent bond, which is stable around neutral pH value (ca. 7.4), but starts to hydrolyze at the extracellular pH value of solid tumors (ca. 6.5) and rapidly disintegrates at endosome and lysosome pH values (ca. 4.5-6.5). This characteristic is promising for the construction of physiological-pH-responsive materials, such as polymeric micelles, nanoparticles, and hydrogels for pharmaceutical and tissue-engineering applications. This Focus Review summarizes recent progress in the design and synthesis of pH-sensitive materials that contain the benzoic imine bond with biomedical objectives.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/35115]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Qu, Xiaozhong,Yang, Zhenzhong. Benzoic-Imine-Based Physiological-pH-Responsive Materials for Biomedical Applications[J]. CHEMISTRY-AN ASIAN JOURNAL,2016,11(19):2633-2641.
APA	Qu, Xiaozhong,&Yang, Zhenzhong.(2016).Benzoic-Imine-Based Physiological-pH-Responsive Materials for Biomedical Applications.CHEMISTRY-AN ASIAN JOURNAL,11(19),2633-2641.
MLA	Qu, Xiaozhong,et al."Benzoic-Imine-Based Physiological-pH-Responsive Materials for Biomedical Applications".CHEMISTRY-AN ASIAN JOURNAL 11.19(2016):2633-2641.