Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles

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	Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles
	Xing, Ruirui 1,2,3; Jiao, Tifeng 1,2; Ma, Kai 2,3; Ma, Guanghui 3; Moehwald, Helmuth 4; Yan, Xuehai 3
刊名	SCIENTIFIC REPORTS
	2016-05-23
卷号	6 期号:MAY 页码:26506
ISSN号	2045-2322
英文摘要	The design of advanced, nanostructured materials by layer-by-layer (LbL) assembly at the molecular level is of great interest because of the broad application of these materials in the biomedical field especially in regulating cell growth, adhesion, movement, differentiation and detachment. Here, we fabricated functional hybrid multilayer films by LbL assembly of biocompatible photosensitizer-coupled polypeptides and collagen-capped gold nanoparticles. The resulting multilayer film can well accommodate cells for adhesion, growth and proliferation. Most significantly, controlled cell apoptosis (detachment) and patterning of the multilayer film is achieved by a photochemical process yielding reactive oxygen species (ROS). Moreover, the site and shape of apoptotic cells can be controlled easily by adjusting the location and shape of the laser beam. The LbL assembled multilayer film with integration of functions provides an efficient platform for regulating cell growth and apoptosis (detachment).
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	MECHANICAL-PROPERTIES ; SURFACES ; FILMS ; POLYELECTROLYTE ; DETACHMENT ; ADHESION ; SYSTEMS ; GROWTH ; TRANSFECTION ; NANOTUBES
收录类别	SCI
语种	英语
WOS记录号	WOS:000376357000001
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/21084]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China 2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Max Planck Inst Colloids & Interfaces, Muhlenberg 1, D-14476 Potsdam, Germany
推荐引用方式 GB/T 7714	Xing, Ruirui,Jiao, Tifeng,Ma, Kai,et al. Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles[J]. SCIENTIFIC REPORTS,2016,6(MAY):26506.
APA	Xing, Ruirui,Jiao, Tifeng,Ma, Kai,Ma, Guanghui,Moehwald, Helmuth,&Yan, Xuehai.(2016).Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles.SCIENTIFIC REPORTS,6(MAY),26506.
MLA	Xing, Ruirui,et al."Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles".SCIENTIFIC REPORTS 6.MAY(2016):26506.