Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse

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	Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse
	Nagaya, K; Motomura, K; Kukk, E; Fukuzawa, H; Wada, S; Tachibana, T; Ito, Y; Mondal, S; Sakai, T; Matsunami, K
刊名	PHYSICAL REVIEW X
	2016
卷号	6 期号:2 页码:—
关键词	IONIZATION CHARGE MOLECULES OPERATION REGION ATOMS
ISSN号	2160-3308
通讯作者	Nagaya, K (reprint author), Kyoto Univ, Grad Sch Sci, Dept Phys, Kyoto 6068502, Japan. ; Nagaya, K (reprint author), RIKEN Spring 8 Ctr, Sayo, Hyogo 6795148, Japan.
英文摘要	Understanding x-ray radiation damage is a crucial issue for both medical applications of x rays and x-ray free-electron-laser (XFEL) science aimed at molecular imaging. Decrypting the charge and fragmentation dynamics of nucleobases, the smallest units of a macro-biomolecule, contributes to a bottom-up understanding of the damage via cascades of phenomena following x-ray exposure. We investigate experimentally and by numerical simulations the ultrafast radiation damage induced on a nucleobase analogue (5-iodouracil) by an ultrashort (10 fs) high-intensity radiation pulse generated by XFEL at SPring-8 Angstrom Compact free electron Laser (SACLA). The present study elucidates a plausible underlying radiosensitizing mechanism of 5-iodouracil. This mechanism is independent of the exact composition of 5-iodouracil and thus relevant to other such radiosensitizers. Furthermore, we found that despite a rapid increase of the net molecular charge in the presence of iodine, and of the ultrafast release of hydrogen, the other atoms are almost frozen within the 10-fs duration of the exposure. This validates single-shot molecular imaging as a consistent approach, provided the radiation pulse used is brief enough.
收录类别	SCI
语种	英语
WOS记录号	WOS:000378057600001
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/25880]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Nagaya, K,Motomura, K,Kukk, E,et al. Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse[J]. PHYSICAL REVIEW X,2016,6(2):—.
APA	Nagaya, K.,Motomura, K.,Kukk, E.,Fukuzawa, H.,Wada, S.,...&Ueda, K.(2016).Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse.PHYSICAL REVIEW X,6(2),—.
MLA	Nagaya, K,et al."Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse".PHYSICAL REVIEW X 6.2(2016):—.