Micro/nano optical fibers for label-free detection of abrin with high sensitivity

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	Micro/nano optical fibers for label-free detection of abrin with high sensitivity
	Liu, G. G. and K. W. Li
刊名	Sensors and Actuators B-Chemical
	2015
卷号	215 页码:146-151
英文摘要	The recognition of abrin is of great civil and military importance. As an alternative to general detecting techniques, such as enzyme-linked immunosorbent assay (ELISA) and electrochemiluminescence (ECL)-based assay, micro/nano optical fibers (MNFs) for the label-free detection of abrin have been investigated for the first time in this paper. The MNFs fabricated through chemical etching are robust and have excellent mechanical strength for practical applications. This MNF-based biosensors feature fast response, high sensitivity, and low cost. A limit of detection of 10 pg/mL was obtained using a MNF with a waist diameter of circa 1.0 mu m, and the typical measurement time was less than 10 min. By taking advantage of the label-free detection, Langmuir kinetics fitting for the dynamic reaction curve suggested a large affinity constant between the antibody and abrin. Regeneration ability of the sensor was also demonstrated by the maintenance of high sensitivity and selectivity after releasing experiments. (C) 2015 Elsevier B.V. All rights reserved.
收录类别	SCI
内容类型	期刊论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/55329]
专题	长春光学精密机械与物理研究所_中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Liu, G. G. and K. W. Li. Micro/nano optical fibers for label-free detection of abrin with high sensitivity[J]. Sensors and Actuators B-Chemical,2015,215:146-151.
APA	Liu, G. G. and K. W. Li.(2015).Micro/nano optical fibers for label-free detection of abrin with high sensitivity.Sensors and Actuators B-Chemical,215,146-151.
MLA	Liu, G. G. and K. W. Li."Micro/nano optical fibers for label-free detection of abrin with high sensitivity".Sensors and Actuators B-Chemical 215(2015):146-151.