Modeling and parameters identification of 2-keto-L-gulonic acid fed-batch fermentation

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	Modeling and parameters identification of 2-keto-L-gulonic acid fed-batch fermentation
	Wang, Tao 1,2; Sun, Jibin 3; Yuan, Jingqi 1,2
刊名	BIOPROCESS AND BIOSYSTEMS ENGINEERING
	2015-04-01
卷号	38 期号:4 页码:605-614
关键词	2-Keto-L-gulonic acid Mixed culture Fed-batch fermentation Modeling and parameters identification Differential evolution algorithm
英文摘要	This article presents a modeling approach for industrial 2-keto-L-gulonic acid (2-KGA) fed-batch fermentation by the mixed culture of Ketogulonicigenium vulgare (K. vulgare) and Bacillus megaterium (B. megaterium). A macrokinetic model of K. vulgare is constructed based on the simplified metabolic pathways. The reaction rates obtained from the macrokinetic model are then coupled into a bioreactor model such that the relationship between substrate feeding rates and the main state variables, e.g., the concentrations of the biomass, substrate and product, is constructed. A differential evolution algorithm using the Lozi map as the random number generator is utilized to perform the model parameters identification, with the industrial data of 2-KGA fed-batch fermentation. Validation results demonstrate that the model simulations of substrate and product concentrations are well in coincidence with the measurements. Furthermore, the model simulations of biomass concentrations reflect principally the growth kinetics of the two microbes in the mixed culture.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Technology
类目[WOS]	Biotechnology & Applied Microbiology ; Engineering, Chemical
研究领域[WOS]	Biotechnology & Applied Microbiology ; Engineering
关键词[WOS]	MACROKINETIC MODEL ; STOICHIOMETRIC BALANCE ; GLUCONOBACTER-OXYDANS ; L-SORBOSE ; VULGARE ; MEGATERIUM ; GROWTH
收录类别	SCI
语种	英语
WOS记录号	WOS:000351513500001
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1440]
专题	天津工业生物技术研究所_系统与合成生物技术实验室孙际宾_期刊论文
作者单位	1.Shanghai Jiao Tong Univ, Dept Automat, Shanghai 200240, Peoples R China 2.Minist Educ China, Key Lab Syst Control & Informat Proc, Shanghai 200240, Peoples R China 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China
推荐引用方式 GB/T 7714	Wang, Tao,Sun, Jibin,Yuan, Jingqi. Modeling and parameters identification of 2-keto-L-gulonic acid fed-batch fermentation[J]. BIOPROCESS AND BIOSYSTEMS ENGINEERING,2015,38(4):605-614.
APA	Wang, Tao,Sun, Jibin,&Yuan, Jingqi.(2015).Modeling and parameters identification of 2-keto-L-gulonic acid fed-batch fermentation.BIOPROCESS AND BIOSYSTEMS ENGINEERING,38(4),605-614.
MLA	Wang, Tao,et al."Modeling and parameters identification of 2-keto-L-gulonic acid fed-batch fermentation".BIOPROCESS AND BIOSYSTEMS ENGINEERING 38.4(2015):605-614.