Antibacterial Drug Leads: DNA and Enzyme Multitargeting

CORC > 天津工业生物技术研究所 > 结构生物学与蛋白酶学实验室郭瑞庭 > 期刊论文

	Antibacterial Drug Leads: DNA and Enzyme Multitargeting
	Zhu, Wei 1; Wang, Yang 1; Li, Kai 1; Gao, Jian 2; Huang, Chun-Hsiang 2; Chen, Chun-Chi 2; Ko, Tzu-Ping 3; Zhang, Yonghui 1; Guo, Rey-Ting 2; Oldfield, Eric 1
刊名	JOURNAL OF MEDICINAL CHEMISTRY
	2015-02-12
卷号	58 期号:3 页码:1215-1227
英文摘要	We report the results of an investigation of the activity of a series of amidine and bisamidine compounds against Staphylococcus aureus and Escherichia coli. The most active compounds bound to an AT-rich DNA dodecamer (CGCGAATTCGCG)(2) and using DSC were found to increase the melting transition by up to 24 degrees C. Several compounds also inhibited undecaprenyl diphosphate synthase (UPPS) with IC50 values of 100-500 nM, and we found good correlations (R-2 = 0.89, S. aureus; R-2 = 0.79, E. coli) between experimental and predicted cell growth inhibition by using DNA Delta(Tm) and UPPS IC50 experimental results together with one computed descriptor. We also solved the structures of three bisamidines binding to DNA as well as three UPPS structures. Overall, the results are of general interest in the context of the development of resistance-resistant antibiotics that involve multitargeting.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Chemistry, Medicinal
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	FARNESYL DIPHOSPHATE SYNTHASE ; ISOPRENOID BIOSYNTHESIS ; BISPHOSPHONATE INHIBITION ; CRYSTAL-STRUCTURE ; TARGET ; D(CGCGAATTCGCG) ; DISCOVERY ; DESIGN
收录类别	SCI
语种	英语
WOS记录号	WOS:000349573800015
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1428]
专题	天津工业生物技术研究所_结构生物学与蛋白酶学实验室郭瑞庭_期刊论文
作者单位	1.Univ Illinois, Dept Chem, Urbana, IL 61801 USA 2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Ind Enzymes Natl Engn Lab, Tianjin 300308, Peoples R China 3.Acad Sinica, Inst Biol Chem, Taipei 11529, Taiwan
推荐引用方式 GB/T 7714	Zhu, Wei,Wang, Yang,Li, Kai,et al. Antibacterial Drug Leads: DNA and Enzyme Multitargeting[J]. JOURNAL OF MEDICINAL CHEMISTRY,2015,58(3):1215-1227.
APA	Zhu, Wei.,Wang, Yang.,Li, Kai.,Gao, Jian.,Huang, Chun-Hsiang.,...&Oldfield, Eric.(2015).Antibacterial Drug Leads: DNA and Enzyme Multitargeting.JOURNAL OF MEDICINAL CHEMISTRY,58(3),1215-1227.
MLA	Zhu, Wei,et al."Antibacterial Drug Leads: DNA and Enzyme Multitargeting".JOURNAL OF MEDICINAL CHEMISTRY 58.3(2015):1215-1227.