Identifying the Association Between Alzheimer's Disease and Parkinson's Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network

	Identifying the Association Between Alzheimer's Disease and Parkinson's Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network
	Liu, Guiyou 1,2; Bao, Xinjie 3,4; Jiang, Yongshuai 5; Liao, Mingzhi 6; Jiang, Qinghua 7; Feng, Rennan 8; Zhang, Liangcai 9; Ma, Guoda 1; Chen, Zugen 10; Wang, Guangyu 11
刊名	MOLECULAR NEUROBIOLOGY
	2015-12-01
卷号	52 期号:3 页码:1629-1636
关键词	Alzheimer's disease Parkinson's disease Genome-wide association studies Gene expression Protein-protein interaction network
英文摘要	Alzheimer's disease (AD) and Parkinson's disease (PD) are the first and second most common neurodegenerative diseases in the elderly. Shared clinical and pathological features have been reported. Recent large-scale genome-wide association studies (GWAS) have been conducted and reported a number of AD and PD variants. Until now, the underlying genetic mechanisms for all these newly identified PD variants as well as the association between AD and PD are still unclear exactly. We think that PD variants may contribute to AD and PD by influence on brain gene expression. Here, we conducted a systems analysis using (1) AD and PD variants (P < 5.00E-08) identified by the published GWAS; (2) four brain expression GWAS datasets using expression quantitative trait loci from the cerebellum and temporal cortex; (3) large-scale AD GWAS from the Alzheimer Disease Genetics Consortium (ADGC); (4) a protein-protein interaction network. Our results indicated that PD variants around the 17q21 were associated with gene expression and suggestive AD risk. We also identified significant interaction among AD and PD susceptibility genes. We believe that our findings may explain the underlying genetic mechanisms for newly identified PD variants in PD and AD, as well as the association between AD and PD, which may be very useful for future genetic studies for both diseases.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	PATHWAY ANALYSIS ; RISK LOCI ; METAANALYSIS ; GENES ; SUSCEPTIBILITY ; POPULATION ; EXPRESSION ; SNCA ; MAPT
收录类别	SCI
语种	英语
WOS记录号	WOS:000361903400047
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1573]
专题	天津工业生物技术研究所_基因组分析实验室陈祖耕_期刊论文
作者单位	1.Guangdong Med Coll, Inst Neurol, Zhanjiang 524001, Peoples R China 2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin Airport Econ Area, Tianjin 300308, Peoples R China 3.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing 100730, Peoples R China 4.Peking Union Med Coll, Beijing 100730, Peoples R China 5.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 6.Northwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China 7.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150006, Peoples R China 8.Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin, Peoples R China 9.Rice Univ, Dept Stat, Houston, TX 77251 USA 10.Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA
推荐引用方式 GB/T 7714	Liu, Guiyou,Bao, Xinjie,Jiang, Yongshuai,et al. Identifying the Association Between Alzheimer's Disease and Parkinson's Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network[J]. MOLECULAR NEUROBIOLOGY,2015,52(3):1629-1636.
APA	Liu, Guiyou.,Bao, Xinjie.,Jiang, Yongshuai.,Liao, Mingzhi.,Jiang, Qinghua.,...&Li, Keshen.(2015).Identifying the Association Between Alzheimer's Disease and Parkinson's Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network.MOLECULAR NEUROBIOLOGY,52(3),1629-1636.
MLA	Liu, Guiyou,et al."Identifying the Association Between Alzheimer's Disease and Parkinson's Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network".MOLECULAR NEUROBIOLOGY 52.3(2015):1629-1636.