Pathway analysis of body mass index genome-wide association study highlights risk pathways in cardiovascular disease

	Pathway analysis of body mass index genome-wide association study highlights risk pathways in cardiovascular disease
	Zhao, Xin 1; Gu, Jinxia 2; Li, Ming 3; Xi, Jie 1; Sun, Wenyu 1; Song, Guangmin 1; Liu, Guiyou 4
刊名	SCIENTIFIC REPORTS
	2015-08-12
卷号	5
英文摘要	Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. It is reported that body mass index (BMI) is risk factor for CVD. Genome-wide association studies (GWAS) have recently provided rapid insights into genetics of CVD and its risk factors. However, the specific mechanisms how BMI influences CVD risk are largely unknown. We think that BMI may influences CVD risk by shared genetic pathways. In order to confirm this view, we conducted a pathway analysis of BMI GWAS, which examined approximately 329,091 single nucleotide polymorphisms from 4763 samples. We identified 31 significant KEGG pathways. There is literature evidence supporting the involvement of GnRH signaling, vascular smooth muscle contraction, dilated cardiomyopathy, Gap junction, Wnt signaling, Calcium signaling and Chemokine signaling in CVD. Collectively, our study supports the potential role of the CVD risk pathways in BMI. BMI may influence CVD risk by the shared genetic pathways. We believe that our results may advance our understanding of BMI mechanisms in CVD.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	CORONARY-ARTERY-DISEASE ; CARDIAC-DISEASE ; LOCI ; METAANALYSIS ; POPULATION ; TRAITS ; SYSTEM
收录类别	SCI
语种	英语
WOS记录号	WOS:000359374500002
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1508]
专题	天津工业生物技术研究所_基因组分析实验室陈祖耕_期刊论文
作者单位	1.Shandong Univ, Qilu Hosp, Dept Cardiac Surg, Jinan 250100, Peoples R China 2.Harbin Med Univ, Affiliated Hosp 4, Dept Cardiol, Harbin 150001, Heilongjiang, Peoples R China 3.Harbin Med Univ, Affiliated Hosp 4, Dept Endocrinol & Metab, Harbin 150001, Heilongjiang, Peoples R China 4.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Beijing 100864, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Xin,Gu, Jinxia,Li, Ming,et al. Pathway analysis of body mass index genome-wide association study highlights risk pathways in cardiovascular disease[J]. SCIENTIFIC REPORTS,2015,5.
APA	Zhao, Xin.,Gu, Jinxia.,Li, Ming.,Xi, Jie.,Sun, Wenyu.,...&Liu, Guiyou.(2015).Pathway analysis of body mass index genome-wide association study highlights risk pathways in cardiovascular disease.SCIENTIFIC REPORTS,5.
MLA	Zhao, Xin,et al."Pathway analysis of body mass index genome-wide association study highlights risk pathways in cardiovascular disease".SCIENTIFIC REPORTS 5(2015).