Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer

	Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer
	Quan, Baoku 1,2; Qi, Xingsi 2,3; Yu, Zhihui 4; Jiang, Yongshuai 5; Liao, Mingzhi 6; Wang, Guangyu 7,8; Feng, Rennan 9; Zhang, Liangcai 10; Chen, Zugen 11; Jiang, Qinghua 12
刊名	MOLECULAR GENETICS AND GENOMICS
	2015-04-01
卷号	290 期号:2 页码:603-610
关键词	Colorectal cancer GWAS Pathway analysis Transcriptome Metabolic pathways
英文摘要	Colorectal cancer (CRC) is a common malignancy that meets the definition of a complex disease. Genome-wide association study (GWAS) has identified several loci of weak predictive value in CRC, however, these do not fully explain the occurrence risk. Recently, gene set analysis has allowed enhanced interpretation of GWAS data in CRC, identifying a number of metabolic pathways as important for disease pathogenesis. Whether there are other important pathways involved in CRC, however, remains unclear. We present a systems analysis of KEGG pathways in CRC using (1) a human CRC GWAS dataset and (2) a human whole transcriptome CRC case-control expression dataset. Analysis of the GWAS dataset revealed significantly enriched KEGG pathways related to metabolism, immune system and diseases, cellular processes, environmental information processing, genetic information processing, and neurodegenerative diseases. Altered gene expression was confirmed in these pathways using the transcriptome dataset. Taken together, these findings not only confirm previous work in this area, but also highlight new biological pathways whose deregulation is critical for CRC. These results contribute to our understanding of disease-causing mechanisms and will prove useful for future genetic and functional studies in CRC.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]	Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]	ALZHEIMERS-DISEASE EVIDENCE ; METABOLIC SYNDROME ; RISK ; GENE ; SUSCEPTIBILITY ; ADENOMA ; SYSTEM
收录类别	SCI
语种	英语
WOS记录号	WOS:000351405200018
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1443]
专题	天津工业生物技术研究所_基因组分析实验室陈祖耕_期刊论文
作者单位	1.First Hosp Harbin, Dept Gen Surg, Harbin, Peoples R China 2.Chinese Acad Sci, Genome Anal Lab, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China 3.First Hosp Harbin, Dept Gastroenterol, Harbin, Peoples R China 4.Heilongjiang Land Reclamat Bur, Gen Hosp, Dept Gastroenterol, Harbin, Peoples R China 5.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 6.Northwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China 7.Harbin Med Univ, Affiliated Tumor Hosp, Dept Gastrointestinal Med Oncol, Harbin, Peoples R China 8.First Hosp Harbin, Dept Oncol, Harbin, Peoples R China 9.Harbin Med Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Harbin, Peoples R China 10.Rice Univ, Dept Stat, Houston, TX 77251 USA
推荐引用方式 GB/T 7714	Quan, Baoku,Qi, Xingsi,Yu, Zhihui,et al. Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer[J]. MOLECULAR GENETICS AND GENOMICS,2015,290(2):603-610.
APA	Quan, Baoku.,Qi, Xingsi.,Yu, Zhihui.,Jiang, Yongshuai.,Liao, Mingzhi.,...&Liu, Guiyou.(2015).Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer.MOLECULAR GENETICS AND GENOMICS,290(2),603-610.
MLA	Quan, Baoku,et al."Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer".MOLECULAR GENETICS AND GENOMICS 290.2(2015):603-610.