CLU rs2279590 polymorphism contributes to Alzheimer's disease susceptibility in Caucasian and Asian populations

	CLU rs2279590 polymorphism contributes to Alzheimer's disease susceptibility in Caucasian and Asian populations
	Zhang, Shuyan 1; Zhang, Donghui 2; Jiang, Yongshuai 3; Wu, Lina 4; Shang, Hong 1; Liu, Jiafeng 2; Feng, Rennan 5; Liao, Mingzhi 3; Zhang, Liangcai 6; Liu, Yong 4
刊名	JOURNAL OF NEURAL TRANSMISSION
	2015-03-01
卷号	122 期号:3 页码:433-439
关键词	Alzheimer's disease Genome-wide association studies CLU rs2279590 polymorphism Caucasian Asian Meta-analysis
英文摘要	It is reported that CLU rs2279590 polymorphism is significantly associated with Alzheimer's disease (AD) in European ancestry. Recent studies investigated rs2279590 polymorphism in Asian population (Chinese, Japanese and Korean). Four studies showed negative association and two studies showed weak association between rs2279590 and AD. We believe that the weak association or no association may be caused by the relatively small sample size in Asian population. Here, we reinvestigated the association in Asian population. Meanwhile, to investigate the genetic heterogeneity of the rs2279590 polymorphism in Asian and Caucasian populations, we searched the PubMed and AlzGene databases and selected 11 independent studies (6 studies in Asian population and 5 studies in Caucasian population) including 20,655 individuals (8,605 cases and 12,050 controls) for meta-analysis. Our results showed significant association between rs2279590 polymorphism and AD in Asian population with P = 2.00E-04 and P = 2.00E-04 using additive and recessive models, respectively. We observed no significant heterogeneity between Asian and Caucasian populations. We believe that our results may be helpful to understand the mechanisms of CLU in AD pathogenesis and will be useful for future genetic studies in AD.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Clinical Neurology ; Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	GENOME-WIDE ASSOCIATION ; GENETIC ASSOCIATION ; IDENTIFIES VARIANTS ; COMMON VARIANTS ; CR-1 ; CD2AP ; EPHA1 ; CD33
收录类别	SCI
语种	英语
WOS记录号	WOS:000350033100012
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1422]
专题	天津工业生物技术研究所_基因组分析实验室陈祖耕_期刊论文
作者单位	1.Harbin Med Univ, Dept Neurol, Forth Affiliated Hosp, Harbin, Peoples R China 2.First Hosp Harbin, Dept Neurosurg, Harbin, Daoli Region, Peoples R China 3.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 4.China Med Univ, Shengjing Hosp, Dept Lab Med, Shenyang 110001, Peoples R China 5.Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin, Peoples R China 6.Rice Univ, Dept Stat, Houston, TX 77251 USA 7.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin Airport Econ Area, Tianjin 300308, Peoples R China 8.Guangdong Med Coll, Inst Neurol, Zhanjiang 524001, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Shuyan,Zhang, Donghui,Jiang, Yongshuai,et al. CLU rs2279590 polymorphism contributes to Alzheimer's disease susceptibility in Caucasian and Asian populations[J]. JOURNAL OF NEURAL TRANSMISSION,2015,122(3):433-439.
APA	Zhang, Shuyan.,Zhang, Donghui.,Jiang, Yongshuai.,Wu, Lina.,Shang, Hong.,...&Li, Keshen.(2015).CLU rs2279590 polymorphism contributes to Alzheimer's disease susceptibility in Caucasian and Asian populations.JOURNAL OF NEURAL TRANSMISSION,122(3),433-439.
MLA	Zhang, Shuyan,et al."CLU rs2279590 polymorphism contributes to Alzheimer's disease susceptibility in Caucasian and Asian populations".JOURNAL OF NEURAL TRANSMISSION 122.3(2015):433-439.