Synergistic Transcriptional and Post-Transcriptional Regulation of ESC Characteristics by Core Pluripotency Transcription Factors in Protein-Protein Interaction Networks

	Synergistic Transcriptional and Post-Transcriptional Regulation of ESC Characteristics by Core Pluripotency Transcription Factors in Protein-Protein Interaction Networks
	Li, Leijie 1; Zhang, Liangcai 2,3; Liu, Guiyou 2,4; Feng, Rennan 2,5; Jiang, Yongshuai 2; Yang, Lei 2; Zhang, Shihua 6; Liao, Mingzhi 1; Hua, Jinlian 7
刊名	PLOS ONE
	2014-08-29
卷号	9 期号:8
英文摘要	The molecular mechanism that maintains the pluripotency of embryonic stem cells (ESCs) is not well understood but may be reflected in complex biological networks. However, there have been few studies on the effects of transcriptional and post-transcriptional regulation during the development of ESCs from the perspective of computational systems biology. In this study, we analyzed the topological properties of the "core'' pluripotency transcription factors (TFs) OCT4, SOX2 and NANOG in protein-protein interaction networks (PPINs). Further, we identified synergistic interactions between these TFs and microRNAs (miRNAs) in PPINs during ESC development. Results show that there were significant differences in centrality characters between TF-targets and non-TF-targets in PPINs. We also found that there was consistent regulation of multiple "core'' pluripotency TFs. Based on the analysis of shortest path length, we found that the module properties were not only within the targets regulated by common or multiple "core'' pluripotency TFs but also between the groups of targets regulated by different TFs. Finally, we identified synergistic regulation of these TFs and miRNAs. In summary, the synergistic effects of "core'' pluripotency TFs and miRNAs were analyzed using computational methods in both human and mouse PPINs.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	EMBRYONIC STEM-CELLS ; HUMAN SOMATIC-CELLS ; BIOLOGICAL NETWORKS ; SELF-RENEWAL ; MOUSE ; NANOG ; OCT4 ; CIRCUITRY ; GENES ; VISUALIZATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000341127500034
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1395]
专题	天津工业生物技术研究所_基因组分析实验室陈祖耕_期刊论文
作者单位	1.Northwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China 2.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 3.Rice Univ, Dept Stat, Houston, TX 77251 USA 4.Chinese Acad Sci, Genome Anal Lab, Tianjin Inst Ind Biotechnol, Tianjin, Peoples R China 5.Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin, Peoples R China 6.Anhui Agr Univ, Sch Sci, Dept Biostat, Hefei, Peoples R China 7.Northwest A&F Univ, Shaanxi Ctr Stem Cells Engn & Technol, Coll Vet Med, Yangling, Shaanxi, Peoples R China
推荐引用方式 GB/T 7714	Li, Leijie,Zhang, Liangcai,Liu, Guiyou,et al. Synergistic Transcriptional and Post-Transcriptional Regulation of ESC Characteristics by Core Pluripotency Transcription Factors in Protein-Protein Interaction Networks[J]. PLOS ONE,2014,9(8).
APA	Li, Leijie.,Zhang, Liangcai.,Liu, Guiyou.,Feng, Rennan.,Jiang, Yongshuai.,...&Hua, Jinlian.(2014).Synergistic Transcriptional and Post-Transcriptional Regulation of ESC Characteristics by Core Pluripotency Transcription Factors in Protein-Protein Interaction Networks.PLOS ONE,9(8).
MLA	Li, Leijie,et al."Synergistic Transcriptional and Post-Transcriptional Regulation of ESC Characteristics by Core Pluripotency Transcription Factors in Protein-Protein Interaction Networks".PLOS ONE 9.8(2014).